Green Jonathan, Jacobs Brian, Beecham Jennifer, Dunn Graham, Kroll Leo, Tobias Catherine, Briskman Jackie
University of Manchester, UK.
J Child Psychol Psychiatry. 2007 Dec;48(12):1259-67. doi: 10.1111/j.1469-7610.2007.01802.x.
Inpatient treatment is a complex intervention for the most serious mental health disorders in child and adolescent psychiatry. This is the first large-scale study into its effectiveness and costs. Previous studies have been criticised for methodological weaknesses.
A prospective cohort study, including economic evaluation, conducted in 8 UK units (total n = 150) with one year follow-up after discharge. Patients acted as their own controls. Outcome measurement was the clinician-rated Childhood Global Assessment Scale (CGAS); researcher-rated health needs assessment; parent- and teacher-rated symptomatology.
We found a significant (p < .001) and clinically meaningful 12-point improvement in CGAS following mean 16.6 week admission (effect size .92); this improvement was sustained at 1 year follow-up. Comparatively, during the mean 16.4 week pre-admission period there was a 3.7-point improvement (effect size .27). Health needs assessment showed similar gain (p < .001, effect size 1.25), as did teacher- and parent-rated symptoms. Improvement was found across all diagnoses. Longer stays, positive therapeutic alliance and better premorbid family functioning independently predicted better outcome. Mean cost of admission was pound 24,100; pre-admission and post-discharge support costs were similar.
Inpatient treatment is associated with substantive sustained health gain across a range of diagnoses. Lack of intensive outpatient-treatment alternatives limits any unqualified inference about causal effects, but the rigour of measurement here gives the strongest indication to date of the positive impact of admission for complex mental health problems in young people.
住院治疗是针对儿童和青少年精神病学中最严重心理健康障碍的一种复杂干预措施。这是对其有效性和成本的首次大规模研究。先前的研究因方法学上的缺陷而受到批评。
一项前瞻性队列研究,包括经济评估,在英国的8个单位进行(总共n = 150),出院后进行一年的随访。患者以自身作为对照。结局测量指标包括临床医生评定的儿童总体评估量表(CGAS);研究人员评定的健康需求评估;家长和教师评定的症状学。
我们发现,平均住院16.6周后,CGAS有显著改善(p <.001),且具有临床意义,提高了12分(效应量为0.92);这种改善在1年随访时得以维持。相比之下,在平均16.4周的入院前期,CGAS有3.7分的改善(效应量为0.27)。健康需求评估显示出类似的改善(p <.001,效应量为1.25),家长和教师评定的症状也有改善。所有诊断类别均有改善。住院时间更长、积极的治疗联盟以及病前家庭功能更好可独立预测更好的结局。平均住院费用为24,100英镑;入院前期和出院后的支持费用相似。
住院治疗与一系列诊断中的实质性持续健康改善相关。缺乏强化门诊治疗替代方案限制了对因果效应的任何无保留推断,但此处测量的严谨性给出了迄今为止关于入院对年轻人复杂心理健康问题产生积极影响的最有力迹象。