Jonsson Colleen B, Hooper Jay, Mertz Gregory
Department of Biochemistry and Molecular Biology, 2000 9th Avenue South, Southern Research Institute, Birmingham, AL 35205, United States.
Antiviral Res. 2008 Apr;78(1):162-9. doi: 10.1016/j.antiviral.2007.10.012. Epub 2007 Nov 21.
Viruses in the genus Hantavirus can cause one of two serious illnesses when transmitted from rodents to humans: hemorrhagic fever with renal syndrome (HFRS) or hantavirus pulmonary syndrome (HPS). Of the two diseases, HPS is more severe with an approximate 40% mortality across the Americas. The high rate of mortality could be reduced if effective therapeutics could be discovered for treatment of this illness. Herein we review approaches being explored for the discovery of therapeutics for HPS and how they could be employed in treatment and prevention of disease.
汉坦病毒属的病毒从啮齿动物传播给人类时，可引发两种严重疾病之一：肾综合征出血热（HFRS）或汉坦病毒肺综合征（HPS）。在这两种疾病中，HPS更为严重，在美洲的死亡率约为40%。如果能发现有效的治疗方法来治疗这种疾病，死亡率可能会降低。在此，我们综述了为发现HPS治疗方法而探索的途径，以及它们如何用于疾病的治疗和预防。
