Navaza Jorge
Laboratoire de Microscopie Electronique Structurale, Institut de Biologie Structurale Jean-Pierre Ebel, 41 Rue Jules Horowitz, F-38027 Grenoble, France.
Acta Crystallogr D Biol Crystallogr. 2008 Jan;64(Pt 1):70-5. doi: 10.1107/S0907444907053334. Epub 2007 Dec 5.
Low-resolution electron-microscopy reconstructions can be used as search models in molecular replacement or may be combined with existing monomeric structures in order to produce multimeric models suitable for molecular replacement. The technique is described in the case of viral and subviral particles as well as in the case of oligomeric proteins.
低分辨率电子显微镜重建可以用作分子置换中的搜索模型,或者与现有的单体结构相结合,以生成适用于分子置换的多聚体模型。该技术在病毒和亚病毒颗粒以及寡聚蛋白的情况下进行了描述。