Arechavala Alicia I, Bianchi Mario H, Robles Ana María, Santiso Gabriela, Negroni Ricardo
Unidad Micología, Hospital de Infecciosas F.J. Muñiz, Buenos Aires, Argentina.
Rev Iberoam Micol. 2007 Dec 31;24(4):305-8. doi: 10.1016/s1130-1406(07)70061-x.
Vulvovaginal candidiasis is a condition that affects a great number of fertile women. It is considered the second cause of genital infection after vaginosis due to GAM complex. Candida albicans is the most frequent isolated species from vaginal discharge. However, sometimes more than one yeast species could be found in the same clinical sample that are more resistant to antifungal drugs. Nowadays, it is necessary to identify properly up to species level the isolated microorganism and to determine the antifungal susceptibility profile. One hundred strains obtained from vaginal discharge of 94 patients suffering acute vulvovaginal candidiasis were studied. The identification of the isolates showed: C. albicans 86%, Candida glabrata 6%, Candida inconspicua 3%, Candida krusei 2% and Candida intermedia, Candida holmii and Trichosporon asahii one case each. Minimal inhibitory concentrations (MIC) of all the yeasts against fluconazole and albaconazole were performed. C. glabrata, C. krusei and C. inconspicua were the most resistant against fluconazole, on the other hand albicans was susceptible to this drug. All the isolates presented MIC against albaconazole much lower than fluconazole.
外阴阴道念珠菌病是一种影响大量育龄妇女的疾病。它被认为是继加德纳菌属相关细菌性阴道病之后生殖器感染的第二大病因。白色念珠菌是从阴道分泌物中最常分离出的菌种。然而，有时在同一临床样本中可发现不止一种酵母菌，且它们对抗真菌药物更具耐药性。如今，有必要将分离出的微生物准确鉴定到种水平，并确定其抗真菌药敏谱。对从94例急性外阴阴道念珠菌病患者的阴道分泌物中获得的100株菌株进行了研究。分离株的鉴定结果显示：白色念珠菌占86%，光滑念珠菌占6%，无名念珠菌占3%，克柔念珠菌占2%，中间念珠菌、霍氏念珠菌和阿萨希丝孢酵母各1例。对所有酵母菌进行了对氟康唑和阿巴康唑的最低抑菌浓度（MIC）检测。光滑念珠菌、克柔念珠菌和无名念珠菌对氟康唑耐药性最强，而白色念珠菌对该药物敏感。所有分离株对阿巴康唑的MIC远低于氟康唑。
