Rhode Jennifer, Fogoros Sarah, Zick Suzanna, Wahl Heather, Griffith Kent A, Huang Jennifer, Liu J Rebecca
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Michigan, Ann Arbor, MI, USA.
BMC Complement Altern Med. 2007 Dec 20;7:44. doi: 10.1186/1472-6882-7-44.
Ginger (Zingiber officinale Rosc) is a natural dietary component with antioxidant and anticarcinogenic properties. The ginger component [6]-gingerol has been shown to exert anti-inflammatory effects through mediation of NF-kappaB. NF-kappaB can be constitutively activated in epithelial ovarian cancer cells and may contribute towards increased transcription and translation of angiogenic factors. In the present study, we investigated the effect of ginger on tumor cell growth and modulation of angiogenic factors in ovarian cancer cells in vitro.
The effect of ginger and the major ginger components on cell growth was determined in a panel of epithelial ovarian cancer cell lines. Activation of NF-kappaB and and production of VEGF and IL-8 was determined in the presence or absence of ginger.
Ginger treatment of cultured ovarian cancer cells induced profound growth inhibition in all cell lines tested. We found that in vitro, 6-shogaol is the most active of the individual ginger components tested. Ginger treatment resulted in inhibition of NF-kB activation as well as diminished secretion of VEGF and IL-8.
Ginger inhibits growth and modulates secretion of angiogenic factors in ovarian cancer cells. The use of dietary agents such as ginger may have potential in the treatment and prevention of ovarian cancer.
生姜（姜科植物姜）是一种具有抗氧化和抗癌特性的天然饮食成分。生姜成分[6]-姜酚已被证明可通过介导核因子κB发挥抗炎作用。核因子κB在上皮性卵巢癌细胞中可被组成性激活，可能有助于血管生成因子转录和翻译的增加。在本研究中，我们在体外研究了生姜对卵巢癌细胞生长和血管生成因子调节的影响。
在一组上皮性卵巢癌细胞系中测定生姜及其主要成分对细胞生长的影响。在有或无生姜的情况下，测定核因子κB的激活以及血管内皮生长因子（VEGF）和白细胞介素-8（IL-8）的产生。
生姜处理培养的卵巢癌细胞在所有测试细胞系中均诱导了显著的生长抑制。我们发现，在体外，6-姜烯酚是所测试的单个生姜成分中活性最高的。生姜处理导致核因子κB激活受到抑制，同时VEGF和IL-8的分泌减少。
生姜抑制卵巢癌细胞生长并调节血管生成因子的分泌。使用如生姜这样的饮食剂可能在卵巢癌的治疗和预防中具有潜力。
