多焦视觉诱发电位视觉功能与海德堡视网膜断层扫描视神经结构的地形图比较

Topographic comparison of the visual function on multifocal visual evoked potentials with optic nerve structure on heidelberg retinal tomography.

作者信息

Punjabi Omar S, Stamper Robert L, Bostrom Alan G, Han Ying, Lin Shan C

机构信息

School of Medicine, University of California San Francisco, San Francisco, California, USA.

出版信息

Ophthalmology. 2008 Mar;115(3):440-6. doi: 10.1016/j.ophtha.2007.10.025. Epub 2007 Dec 21.

DOI:10.1016/j.ophtha.2007.10.025

PMID:18096233

Abstract

PURPOSE

The authors' objective was to compare the visual field obtained using multifocal visual evoked potential (mfVEP) testing with the optic nerve parameters of Heidelberg retinal tomography (HRT; Heidelberg Engineering, Heidelberg, Germany; software version 2.01) in primary open-angle glaucoma (POAG) patients and normal controls and to determine which parameters correlate with visual function.

DESIGN

Cross-sectional study.

PARTICIPANTS

Eighty-one eyes of 42 adult POAG patients and normal controls between the ages of 40 and 80 years, of which 35 patients (67 eyes; mean age+/-standard deviation [SD], 68+/-10 years) had POAG, and 7 individuals who served as normal controls (14 eyes; mean age+/-SD, 61+/-10 years) were included.

METHODS

A monocular mfVEP test, the AccuMap (Opera software version 2.0; ObjectiVision Pty. Ltd., Sydney, Australia), with a 58-sector pattern-reversal dart board array was recorded in both eyes per patient. These patients underwent the HRT 2 and mfVEP tests within 3 months of each other.

MAIN OUTCOME MEASURES

Amplitudes in the superior hemisphere of the mfVEP trace were compared with the HRT parameters in the inferior hemisphere of the HRT and vice versa using mixed effects regression models.

RESULTS

Amplitudes on the superior hemisphere of the mfVEP recordings showed a significant direct correlation with rim-to-disc area ratio (P = 0.0037), rim volume (P = 0.0421), and mean retinal nerve fiber layer (RNFL) thickness (P = 0.0016) and a significant inverse correlation with cup area (P = 0.0009) and cup-to-disc area ratio (P = 0.0037) in the inferior hemisphere of the HRT results. Amplitudes on the inferior hemisphere showed a significant direct correlation with rim-to-disc area ratio (P = 0.036) and a significant inverse correlation with cup area (P = 0.0007), cup-to-disc area ratio (P = 0.036), cup volume (P<0.0001), and mean cup depth (P = 0.0012) in the superior hemisphere of the HRT results.

CONCLUSIONS

Results from mfVEP and HRT showed correlation between visual function and optic nerve structure.

摘要

目的

作者的目的是比较在原发性开角型青光眼（POAG）患者和正常对照中，使用多焦视觉诱发电位（mfVEP）测试获得的视野与海德堡视网膜断层扫描（HRT；德国海德堡海德堡工程公司；软件版本2.01）的视神经参数，并确定哪些参数与视觉功能相关。

设计

横断面研究。

参与者

42名年龄在40至80岁之间的成年POAG患者和正常对照的81只眼睛，其中35名患者（67只眼睛；平均年龄±标准差[SD]，68±10岁）患有POAG，7名作为正常对照的个体（14只眼睛；平均年龄±SD，61±10岁）被纳入。

方法

对每位患者的双眼进行单眼mfVEP测试，即AccuMap（Opera软件版本2.0；澳大利亚悉尼ObjectiVision Pty. Ltd.），采用58扇区模式反转飞镖板阵列。这些患者在彼此3个月内接受了HRT 2和mfVEP测试。

主要观察指标

使用混合效应回归模型，将mfVEP轨迹上半视野的振幅与HRT下半视野的参数进行比较，反之亦然。

结果

mfVEP记录上半视野的振幅与HRT结果下半视野的视盘边缘面积比（P = 0.0037）、边缘体积（P = 0.0421）和平均视网膜神经纤维层（RNFL）厚度（P = 0.0016）呈显著正相关，与杯盘面积（P = 0.0009）和杯盘面积比（P = 0.0037）呈显著负相关。下半视野的振幅与HRT结果上半视野的视盘边缘面积比（P = 0.036）呈显著正相关，与杯盘面积（P = 0.0007）、杯盘面积比（P = 0.036）、杯体积（P<0.0001）和平均杯深度（P = 0.0012）呈显著负相关。