Liu Haitao, Liao Fei, Blanco Román, de la Villa Pedro
Physiology Unit, Department of Systems Biology, School of Medicine, University of Alcalá, 28005 Madrid, Spain.
Department of Surgery, School of Medicine, University of Alcalá, 28005 Madrid, Spain.
J Clin Med. 2021 Sep 15;10(18):4165. doi: 10.3390/jcm10184165.
Some discrepancies have been observed in the diagnostic efficacy of multifocal visual evoked potential (mfVEP) when evaluating visual field defects in glaucoma patients. Therefore, we evaluated the diagnostic precision of the mfVEP in glaucoma to find its best diagnostic indicator. A systematic review and meta-analysis of quantitative studies published up to 1 April 2021 was performed. The methodological quality of the included articles was assessed. Publication bias analysis and heterogeneity tests were performed. The sensitivity, specificity and diagnostic odds ratio were calculated. The area under the curve (AUC) was calculated using the summary of receiver operating characteristics curve. Six studies with a total of 241 patients were included according to the inclusion and exclusion criteria. The AUC was 0.98. There was no evidence of publication bias or threshold effect. The pooled sensitivity and pooled specificity of the mfVEP amplitude for detection of visual field defects in all studies was 0.93 and 0.89, respectively. The positive and negative likelihood ratios of mfVEP amplitude were 6.56 and 0.08, respectively. The amplitude of mfVEP showed a good diagnostic precision in the prediction of visual field defects. Interocular mfVEP amplitude analysis can be a good diagnostic indicator for visual field study.
在评估青光眼患者的视野缺损时，多焦视觉诱发电位（mfVEP）的诊断效能存在一些差异。因此，我们评估了mfVEP在青光眼诊断中的准确性，以找到其最佳诊断指标。我们对截至2021年4月1日发表的定量研究进行了系统评价和荟萃分析。评估了纳入文章的方法学质量。进行了发表偏倚分析和异质性检验。计算了敏感性、特异性和诊断比值比。使用受试者工作特征曲线的汇总计算曲线下面积（AUC）。根据纳入和排除标准，纳入了6项研究，共241例患者。AUC为0.98。没有证据表明存在发表偏倚或阈值效应。在所有研究中，mfVEP振幅检测视野缺损的合并敏感性和合并特异性分别为0.93和0.89。mfVEP振幅的阳性和阴性似然比分别为6.56和0.08。mfVEP振幅在预测视野缺损方面显示出良好的诊断准确性。双眼mfVEP振幅分析可以成为视野研究的良好诊断指标。
