Zamrini E Y, Meador K J, Thompson W O, Lee G P
Department of Neurology Medical College of Georgia, Augusta 30912-3275.
Int J Neurosci. 1991 Nov;61(1-2):113-20. doi: 10.3109/00207459108986279.
The P3 event-related potential has been widely employed in both clinical and research investigations. In the present study, P3 latency and amplitude intersession reliability were evaluated in 4 sessions over an average of 33 days in 24 healthy adults using the P3 tonal oddball paradigm. Mean group latencies ranged from 302-305 ms and mean amplitudes ranged from 7.75-8.87 microV. No significant group differences were found across sessions for latency or amplitude. Intrasubject variability was large; the 95% confidence interval for the difference between the means of two combined sessions was +/- 20 ms for latency and +/- 4.63 microV for amplitude. The results suggest that P3 latency and amplitude are reliable and reproducible over weeks for groups, but have greater variability for individuals.
P3事件相关电位已广泛应用于临床和研究调查。在本研究中，使用P3音调奇偶数范式，对24名健康成年人在平均33天的4次测试中评估了P3潜伏期和波幅的组间可靠性。平均组潜伏期范围为302 - 305毫秒，平均波幅范围为7.75 - 8.87微伏。在各测试期间，潜伏期或波幅均未发现显著的组间差异。个体内变异性较大；两次合并测试均值之差的95%置信区间，潜伏期为±20毫秒，波幅为±4.63微伏。结果表明，P3潜伏期和波幅在数周内对于群体而言是可靠且可重复的，但个体的变异性更大。
