Sklare D A, Lynn G E
Electroencephalogr Clin Neurophysiol. 1984 Sep;59(5):420-4. doi: 10.1016/0168-5597(84)90043-1.
A growing body of research has focused on the P3 (P300) event-related potential as an electrophysiological correlate of selective attention. The present investigation examines the intrasubject test-retest reliability of the auditory evoked P3 latency measure for neurologically and audiologically normal young adults aged 22-34 years across test sessions separated by 2-4 weeks (N = 9) and across trials within one test session (N = 20). In a target-selection ('oddball') paradigm, subjects mentally counted infrequent 2 kHz tone bursts (targets) randomly interspersed within a sequence of 1 kHz tone bursts (non-targets). A strong positive correlation was demonstrated between latencies of test sessions I and II. An analysis of variance did not demonstrate statistically significant latency differences as a function of either tests or trials for the test-retest group (N = 9). Although analysis of variance demonstrated a statistically significant difference between trials within one test session for 20 subjects, the small mean latency difference between trials (4.7 msec) is interpreted as being clinically unimportant. The stability of P3 latency found in this study over a period of 2-4 weeks supports its application to the study of normal and disordered cognitive processes.
越来越多的研究聚焦于P3（P300）事件相关电位，将其作为选择性注意的电生理关联指标。本研究考察了22至34岁神经和听力正常的年轻成年人听觉诱发P3潜伏期测量在2至4周间隔的测试时段内（N = 9）以及一个测试时段内的多次试验（N = 20）中的受试者内重测信度。在目标选择（“oddball”）范式中，受试者在一系列1千赫纯音脉冲（非目标）中默数随机穿插的罕见2千赫纯音脉冲（目标）。测试时段I和II的潜伏期之间显示出强正相关。方差分析未显示重测组（N = 9）的潜伏期因测试或试验而存在统计学显著差异。尽管方差分析显示20名受试者在一个测试时段内的试验之间存在统计学显著差异，但试验之间较小的平均潜伏期差异（4.7毫秒）在临床上被认为不重要。本研究中发现的P3潜伏期在2至4周内的稳定性支持了其在正常和紊乱认知过程研究中的应用。
