Heo Jin-Chul, Woo Sang-Uk, Kweon Mi-Ae, Park Ja-Young, Lee Hee Kyung, Son Minsik, Rho Jae-Rang, Lee Sang-Han
Food and Bio-Industry Research Institute, Kyungpook National University, Daegu 702-701, Korea.
Int J Mol Med. 2008 Jan;21(1):57-61.
Molecular inflammation is a pivotal process in various degenerative immune diseases, including asthma and atopic dermatitis. In this study, we examined the effects of Helianthus annuus seed (HAS) aqueous extract on an in vivo anti-asthmatic model. Ovalbumin-induced mice were orally administered the aqueous extract of Helianthus annuus seeds, and their lungs were assessed by hematoxylin and eosin staining. Moreover, the expression levels of IL-4/IL-13 cytokines and IgE were determined. HAS extract induced a decrease in CD4+ cell number, IL-4/IL-13 expression, and IgE secretion levels in the lungs. Our findings collectively suggest that the HAS extract has considerable potential in reducing the asthma-like symptoms induced by a mouse ovalbumin challenge model. However, further isolation and purification of the extract is required to determine the specific factor(s) responsible for its anti-asthmatic activity.
分子炎症是包括哮喘和特应性皮炎在内的各种退行性免疫疾病中的关键过程。在本研究中，我们研究了向日葵籽（HAS）水提取物对体内抗哮喘模型的影响。用卵清蛋白诱导小鼠，然后口服给予向日葵籽水提取物，并用苏木精和伊红染色评估其肺部情况。此外，还测定了IL-4/IL-13细胞因子和IgE的表达水平。HAS提取物导致肺中CD4+细胞数量、IL-4/IL-13表达和IgE分泌水平降低。我们的研究结果共同表明，HAS提取物在减轻小鼠卵清蛋白激发模型诱导的哮喘样症状方面具有相当大的潜力。然而，需要对提取物进行进一步的分离和纯化，以确定其抗哮喘活性的具体因子。
