Akar Servet, Can Gercek, Binicier Omer, Aksu Kenan, Akinci Baris, Solmaz Dilek, Birlik Merih, Keser Gökhan, Akkoc Nurullah, Onen Fatos
Division of Rheumatology, Department of Internal Medicine, Dokuz Eylul University School of Medicine, Dokuz Eylul Universitesi Tip Fakultesi, Ic Hastaliklari AD, Immunoloji-Romatoloji BD, Inciralti, 35340 Izmir, Turkey.
Clin Rheumatol. 2008 Jul;27(7):859-65. doi: 10.1007/s10067-007-0813-9. Epub 2007 Dec 21.
The aims of the study were to assess the health-related quality of life (QOL) in patients with Takayasu's arteritis (TA) by two different generic QOL instruments and to compare the results with those patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS), and healthy controls (HC). A cross-sectional study was performed in 51 patients with TA (41 women; mean age 38.4 +/- 13.5), 43 RA (36 women; 55.2 +/- 9.6), 31 AS (12 women; 41.2 +/- 13.1), and 75 HC (53 women; 38.8 +/- 10.9). Quality of life was assessed by using Short-Form 36 (SF-36) and Nottingham Health Profile (NHP). Separate dimensions of SF-36 and NHP and physical and mental summary scores of SF-36 as well were compared between patients and control groups. Physical and mental health summary scores and all SF-36 subscales, except for social functioning, were significantly lower in patients with TA than healthy controls. No significant differences between TA, RA, and AS patients were found in all SF-36 subscales and summary scores. NHP scores for energy level, pain, emotional reactions, and physical mobility were significantly higher in TA patients than controls. All NHP subscales, except for pain, were comparable in patients with TA, RA, and AS. Pain score was worse in RA patients. The NHP scores for sleep and social isolation were not different between patients and controls. Many aspects of QOL in patients with TA are significantly impaired in comparison with local healthy controls and similar to those in patients with RA and AS.
本研究的目的是通过两种不同的通用生活质量工具评估大动脉炎（TA）患者的健康相关生活质量（QOL），并将结果与类风湿关节炎（RA）、强直性脊柱炎（AS）患者及健康对照（HC）进行比较。对51例TA患者（41例女性；平均年龄38.4±13.5岁）、43例RA患者（36例女性；55.2±9.6岁）、31例AS患者（12例女性；41.2±13.1岁）和75例HC（53例女性；38.8±10.9岁）进行了横断面研究。使用简短健康调查问卷36项版（SF-36）和诺丁汉健康量表（NHP）评估生活质量。比较了患者组和对照组之间SF-36和NHP的各个维度以及SF-36的生理和心理综合评分。TA患者的生理和心理健康综合评分以及除社会功能外的所有SF-36子量表得分均显著低于健康对照组。在所有SF-36子量表和综合评分中，TA、RA和AS患者之间未发现显著差异。TA患者的NHP能量水平、疼痛、情绪反应和身体活动能力得分显著高于对照组。除疼痛外，TA、RA和AS患者的所有NHP子量表得分相当。RA患者的疼痛评分更差。患者和对照组之间的NHP睡眠和社会隔离得分没有差异。与当地健康对照组相比，TA患者生活质量的许多方面显著受损，且与RA和AS患者相似。
