Kovacic Peter, Pozos Robert S, Draskovich Christine D
Department of Chemistry, San Diego State University, San Diego, California 921812, USA.
J Recept Signal Transduct Res. 2007;27(5-6):411-31. doi: 10.1080/10799890701699686.
A prior article in skeletal form proposed an electrostatic mechanism for receptor-ligand activity. The present review provides an elaboration, including supporting evidence. The fundamental aspect entails the presence of molecular electrostatic potential associated with ions and dipoles in the ligand. The ligand can be regarded as an electrical link that joins prevalent electrostatic fields present in the surrounding protein matrix. The exact role of these fields is speculative. One possibility is to function as conduits for electrons and radicals in cell signaling. There is increasing support for important participation of these species in signal transduction. There might also be a favorable influence on energetics involving the electron transfer process. A summary of receptor biology is also provided, including receptors for acetylcholine (nicotinic and muscarinic), GABA, adrenergic, and glutamate.
之前一篇梗概形式的文章提出了一种受体-配体活性的静电机制。本综述对此进行了详细阐述，包括支持证据。其基本方面涉及配体中与离子和偶极相关的分子静电势的存在。配体可被视为连接周围蛋白质基质中普遍存在的静电场的电连接。这些场的确切作用是推测性的。一种可能性是在细胞信号传导中充当电子和自由基的传导途径。越来越多的证据支持这些物质在信号转导中发挥重要作用。这也可能对涉及电子转移过程的能量学产生有利影响。本文还提供了受体生物学的概述，包括乙酰胆碱（烟碱型和毒蕈碱型）、γ-氨基丁酸、肾上腺素能和谷氨酸的受体。
