Demidov V N, Lipatenkova J, Vikhareva O, Van Holsbeke C, Timmerman D, Valentin L
Federal Governmental Institution Science Center of Obstetrics, Gynecology and Perinatology of Russian Medical Technologies, Moscow, Russia.
Ultrasound Obstet Gynecol. 2008 Jan;31(1):85-91. doi: 10.1002/uog.5227.
To describe the clinical history and ultrasound findings in women with ovarian Sertoli cell, Sertoli-Leydig cell and Leydig cell tumors.
Women with a histological diagnosis of Sertoli cell tumor, Sertoli-Leydig cell tumor or Leydig cell tumor who had undergone preoperative ultrasound examination were identified from the databases of each of three participating ultrasound centers. The tumors were characterized on the basis of ultrasound images, ultrasound reports and research protocols (when applicable) using the terms and definitions published by the International Ovarian Tumor Analysis (IOTA) group. In addition, all images were reviewed and described using pattern recognition.
Of 22 patients identified, 15 had Sertoli-Leydig cell tumors, two had Sertoli cell tumors and five had Leydig cell tumors. Four patients were postmenopausal, one 48-year-old woman had undergone hysterectomy, 16 were of fertile age and one was a 4-year-old girl. Most patients (82%, 18/22) had endocrine symptoms, the most common being bleeding disturbance (64%, 14/22) and hirsutism (32%, 7/22). Twenty-two (96%) of 23 tumors (one woman had bilateral tumors) contained a solid component; 16 (70%) were purely solid. Pattern recognition showed that the Leydig cell tumors were small solid tumors (four of five had a largest diameter of 1-3 cm) and the two Sertoli cell tumors were somewhat larger solid tumors (4 cm and 7 cm); the Sertoli-Leydig cell tumors were either small (3-4 cm) or medium-sized (6-7 cm) solid tumors, or multilocular solid tumors of any size (3-18 cm) with purely solid areas mixed with areas of innumerable closely packed small cyst locules.
On the basis of endocrine symptoms, the woman's age and ultrasound findings, it should be possible to suggest a correct preoperative diagnosis of Sertoli cell, Sertoli-Leydig cell or Leydig cell tumors in many cases.
描述患有卵巢支持细胞瘤、支持-间质细胞瘤和间质细胞瘤的女性的临床病史及超声检查结果。
从三个参与研究的超声中心的数据库中，识别出术前接受过超声检查且组织学诊断为支持细胞瘤、支持-间质细胞瘤或间质细胞瘤的女性。根据国际卵巢肿瘤分析（IOTA）小组发布的术语和定义，基于超声图像、超声报告及研究方案（如适用）对肿瘤进行特征描述。此外，使用模式识别对所有图像进行回顾和描述。
在识别出的22例患者中，15例患有支持-间质细胞瘤，2例患有支持细胞瘤，5例患有间质细胞瘤。4例患者为绝经后女性，1例48岁女性已接受子宫切除术，16例为育龄期女性，1例为4岁女童。大多数患者（82%，18/22）有内分泌症状，最常见的是出血紊乱（64%，14/22）和多毛症（32%，7/22）。23个肿瘤（1名女性为双侧肿瘤）中有22个（96%）含有实性成分；16个（70%）为纯实性。模式识别显示，间质细胞瘤为小实性肿瘤（5个中有4个最大直径为1 - 3 cm），2个支持细胞瘤为稍大的实性肿瘤（4 cm和7 cm）；支持-间质细胞瘤为小（3 - 4 cm）或中等大小（6 - 7 cm）的实性肿瘤，或任何大小（3 - 18 cm）的多房实性肿瘤，其纯实性区域与无数紧密排列的小囊腔区域混合。
基于内分泌症状、患者年龄及超声检查结果，在许多情况下应能够对支持细胞瘤、支持-间质细胞瘤或间质细胞瘤做出正确的术前诊断。
