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1
Development of resistance to ciprofloxacin in nutrient-rich and nutrient-limited growth conditions in vitro by Pseudomonas aeruginosa isolates from patients with cystic fibrosis.囊性纤维化患者分离出的铜绿假单胞菌在富含营养和营养受限的体外生长条件下对环丙沙星耐药性的发展
Antimicrob Agents Chemother. 1991 Dec;35(12):2649-51. doi: 10.1128/AAC.35.12.2649.
2
Comparison of inhibitory and bactericidal activity of antipseudomonal antibiotics against Pseudomonas aeruginosa isolates from cystic fibrosis patients.抗铜绿假单胞菌抗生素对囊性纤维化患者分离出的铜绿假单胞菌的抑菌和杀菌活性比较。
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3
Resistance to ciprofloxacin of respiratory pathogens in patients with cystic fibrosis.
Med J Aust. 1992 Jan 6;156(1):20-4. doi: 10.5694/j.1326-5377.1992.tb121473.x.
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Comparison of the Micronaut Merlin automated broth microtiter system with the standard agar dilution method for antimicrobial susceptibility testing of mucoid and nonmucoid Pseudomonas aeruginosa isolates from cystic fibrosis patients.将Micronaut Merlin自动肉汤微量滴定系统与标准琼脂稀释法用于囊性纤维化患者黏液型和非黏液型铜绿假单胞菌分离株抗菌药敏试验的比较。
Eur J Clin Microbiol Infect Dis. 2004 Oct;23(10):765-71. doi: 10.1007/s10096-004-1212-7.
5
Investigation into the selection frequency of resistant mutants and the bacterial kill rate by levofloxacin and ciprofloxacin in non-mucoid Pseudomonas aeruginosa isolates from cystic fibrosis patients.对囊性纤维化患者非黏液型铜绿假单胞菌分离株中耐药突变体的选择频率以及左氧氟沙星和环丙沙星的细菌杀灭率的调查。
Int J Antimicrob Agents. 2002 May;19(5):377-82. doi: 10.1016/s0924-8579(02)00017-1.
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Synergy of ciprofloxacin with fosfomycin in vitro against Pseudomonas isolates from patients with cystic fibrosis.环丙沙星与磷霉素对囊性纤维化患者分离出的铜绿假单胞菌的体外协同作用。
J Antimicrob Chemother. 1988 Jul;22(1):41-50. doi: 10.1093/jac/22.1.41.
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Resistance to ciprofloxacin of respiratory pathogens in patients with cystic fibrosis.
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Evaluation of E-Test for determination of antimicrobial MICs for Pseudomonas aeruginosa isolates from cystic fibrosis patients.评估E试验法测定囊性纤维化患者铜绿假单胞菌分离株的抗菌药物最低抑菌浓度。
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In-vitro activity of ciprofloxacin and other antibacterial agents against Pseudomonas aeruginosa and Pseudomonas cepacia from cystic fibrosis patients.环丙沙星及其他抗菌药物对囊性纤维化患者铜绿假单胞菌和洋葱伯克霍尔德菌的体外活性。
J Antimicrob Chemother. 1985 Jun;15(6):679-84. doi: 10.1093/jac/15.6.679.
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Activities of tobramycin and six other antibiotics against Pseudomonas aeruginosa isolates from patients with cystic fibrosis.妥布霉素及其他六种抗生素对囊性纤维化患者分离出的铜绿假单胞菌的活性。
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Bacterial antibiotic resistance development and mutagenesis following exposure to subinhibitory concentrations of fluoroquinolones : a systematic review of the literature.暴露于亚抑菌浓度氟喹诺酮类药物后细菌抗生素耐药性的发展及诱变：文献系统综述
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Complex ciprofloxacin resistome revealed by screening a Pseudomonas aeruginosa mutant library for altered susceptibility.通过筛选铜绿假单胞菌突变体文库以检测敏感性变化揭示的复杂环丙沙星耐药组
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本文引用的文献

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Bacterial adherence to epithelial cells in bacillary colonization of the respiratory tract.细菌在呼吸道杆菌定植过程中对上皮细胞的黏附。
Am Rev Respir Dis. 1980 Jan;121(1):55-63. doi: 10.1164/arrd.1980.121.1.55.
2
In-vitro studies with ciprofloxacin, a new 4-quinolone compound.使用新型4-喹诺酮化合物环丙沙星进行的体外研究。
J Antimicrob Chemother. 1984 Apr;13(4):333-46. doi: 10.1093/jac/13.4.333.
3
Rapid selection of organisms with increasing resistance on subinhibitory concentrations of norfloxacin in agar.在琼脂中对亚抑菌浓度的诺氟沙星产生耐药性增加的微生物的快速筛选。
Antimicrob Agents Chemother. 1983 Jan;23(1):188-9. doi: 10.1128/AAC.23.1.188.
4
Generation times of Proteus mirabilis and Escherichia coli in experimental infections.奇异变形杆菌和大肠杆菌在实验性感染中的代时。
Chemotherapy. 1973;19(3):161-70. doi: 10.1159/000221451.
5
Influence of substrate limitation and growth phase on sensitivity to antimicrobial agents.底物限制和生长阶段对抗菌剂敏感性的影响。
J Antimicrob Chemother. 1985 Jan;15 Suppl A:7-14. doi: 10.1093/jac/15.suppl_a.7.
6
Ciprofloxacin therapy in cystic fibrosis.环丙沙星在囊性纤维化治疗中的应用
J Antimicrob Chemother. 1987 Sep;20(3):295-6. doi: 10.1093/jac/20.3.295.
7
Randomized study of two dosage regimens of ciprofloxacin for treating chronic bronchopulmonary infection in patients with cystic fibrosis.环丙沙星两种给药方案治疗囊性纤维化患者慢性支气管肺部感染的随机研究。
Am J Med. 1987 Apr 27;82(4A):189-95.
8
Ciprofloxacin monotherapy for acute pulmonary exacerbations of cystic fibrosis.环丙沙星单药治疗囊性纤维化急性肺部加重期
Am J Med. 1987 Apr 27;82(4A):174-9.
9
In-vitro selection of bacteria resistant to the 4-quinolone agents.
J Antimicrob Chemother. 1987 Jan;19(1):65-71. doi: 10.1093/jac/19.1.65.
10
Oral ciprofloxacin therapy of infections due to Pseudomonas aeruginosa.口服环丙沙星治疗铜绿假单胞菌感染
Lancet. 1986 Apr 12;1(8485):819-22. doi: 10.1016/s0140-6736(86)90937-2.

囊性纤维化患者分离出的铜绿假单胞菌在富含营养和营养受限的体外生长条件下对环丙沙星耐药性的发展

Development of resistance to ciprofloxacin in nutrient-rich and nutrient-limited growth conditions in vitro by Pseudomonas aeruginosa isolates from patients with cystic fibrosis.

作者信息

Ferguson M I, Scott E M, Collier P S

机构信息

School of Pharmacy, Queen's University of Belfast, Northern Ireland.

出版信息

Antimicrob Agents Chemother. 1991 Dec;35(12):2649-51. doi: 10.1128/AAC.35.12.2649.

DOI:10.1128/AAC.35.12.2649
PMID:1810202
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC245449/
Abstract

Five serial exposures of mucoid Pseudomonas aeruginosa from patients with cystic fibrosis to subinhibitory concentrations of ciprofloxacin resulted in stepwise increases in the MIC, with a mean proportional increase of 10. MICs were significantly lower in an iron-limited chemically defined medium than in Iso-Sensitest broth. The mucoid phenotype was maintained in chemically defined medium. Acquired resistance was retained either partially or completely in 85% of the isolates following 10 transfers in drug-free media. In cases in which susceptibility was regained, an increase in the MIC was observed on one further exposure to ciprofloxacin.

摘要

对来自囊性纤维化患者的黏液型铜绿假单胞菌进行五次连续暴露于亚抑菌浓度的环丙沙星后，其最低抑菌浓度（MIC）呈逐步上升，平均比例增加了10倍。在铁限制的化学限定培养基中，MIC显著低于在异感测试肉汤中的MIC。黏液型表型在化学限定培养基中得以维持。在无药物培养基中传代10次后，85%的分离株部分或完全保留了获得性耐药性。在恢复药敏性的病例中，再次暴露于环丙沙星时观察到MIC有所增加。