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N,N'-双-/3-氮丙啶/丁酰亚烷基二胺及3-氮丙啶琥珀酸亚胺的某些衍生物的合成与免疫药理学分析。I

Synthesis and immunopharmacological analysis of selected derivatives of N,N'-bis-/3-aziridine/butanoylalkylenediamines and imides of 3-aziridinesuccinic acid. I.

作者信息

Kowalczyk-Bronisz S H, Mojsiejewska D, Pomorski J

机构信息

Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław.

出版信息

Arch Immunol Ther Exp (Warsz). 1991;39(3):261-9.

PMID:1810218
Abstract

A series of aziridinederivatives of N,N'-bis-butanoylalkylenodiamines (Scheme 1, 1-4) and aziridinederivatives of substituted succinic acid (Scheme 2, 16-19) was obtained. Pharmacological analysis revealed that these compounds were immunotropic, of marked suppressive effect (PFC, RFC, circulating immunoglobulins). Outstanding in this group was phenyloimide of succinic acid (prep. 16) which reduced PFC and RFC number but increased the level of circulating IgG.

摘要

得到了一系列N,N'-双丁酰亚烷基二胺的氮丙啶衍生物（方案1，1-4）和取代琥珀酸的氮丙啶衍生物（方案2，16-19）。药理分析表明，这些化合物具有免疫调节作用，有显著的抑制效果（PFC、RFC、循环免疫球蛋白）。该组中突出的是琥珀酸苯酰亚胺（制剂16），它降低了PFC和RFC数量，但提高了循环IgG水平。

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