Kowalczyk-Bronisz S H, Pomorski J
Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław.
Arch Immunol Ther Exp (Warsz). 1991;39(3):271-7.
In the reaction of butanic and butanodionic acid chlorides with amines, amides 1-10 were produced. Addition of aziridine to a double bonds was performed in alkaline medium which resulted in aziridine derivatives of both acids. Pharmacological study revealed that the preparations examined possess immunotropic, strongly suppressive activity (PFC, E-RFC), partly IgG level; they leave the titer of circulating IgM unchanged. It seems that rather the basic system of acids than the substituents introduced to it are responsible for the effect of the compounds.
在丁酸和丁二酸氯化物与胺的反应中，生成了酰胺1 - 10。在碱性介质中，氮丙啶加成到双键上，生成了两种酸的氮丙啶衍生物。药理学研究表明，所检测的制剂具有免疫调节、强抑制活性（PFC、E - RFC），部分影响IgG水平；它们使循环IgM的滴度保持不变。似乎是酸的基本体系而非引入的取代基对这些化合物的作用负责。
