Pomorski J, Kowalczyk-Bronisz S H, Mojsiejewska D
Department of Drugs Chemistry, Medical Academy, Wrocław.
Arch Immunol Ther Exp (Warsz). 1992;40(3-4):217-22.
A series of aminocarbamic acid derivatives, containing fragments of substituted hydrazine and dithiocarbamic acid, was synthesized. The immunopharmacologic studies showed these that derivatives exerted immunotropic, mainly suppressive effects (PFC, circulating immunoglobulins, E-RFC, A-RFC). Some of these compounds, however, caused significant increase of weight of the popliteal lymph nodes. The immunotropic activity of the newly synthesized preparations is comparable with the action of sodium diethyldithiocarbamate (imuthiol).
合成了一系列含有取代肼和二硫代氨基甲酸片段的氨基甲酸衍生物。免疫药理学研究表明，这些衍生物具有免疫调节作用，主要是抑制作用（空斑形成细胞、循环免疫球蛋白、E-玫瑰花结形成细胞、A-玫瑰花结形成细胞）。然而，其中一些化合物导致腘淋巴结重量显著增加。新合成制剂的免疫调节活性与二乙氨基二硫代甲酸钠（氨硫脲）的作用相当。
