[5-碘脱氧尿苷诱导内源性C型病毒及多环烃增强这种诱导作用]

[Induction of endogenous C-type virus by 5-iododeoxyuridine and augmentation of this induction by polycyclic hydrocarbons].

作者信息

Yoshikura H, Zajdela F

出版信息

C R Acad Hebd Seances Acad Sci D. 1976 Apr 5;282(14):1383-5.

Abstract

When the MLg Mouse cells were treated with the chemical carcinogens, in the presence of microsomal enzymes and NADPH2 after 5-iododeoxyuridine (IUdR) treatment, the induction frequency of the endogenous C-type virus was increased by nearly 10-fold in comparison with the cultures treated with IUdR only. In the preliminary screening of several polycyclic hydrocarbons including carcinogenic and non-carcinogenic products, apparently there was no correlation between the carcinogenecity in vivo and the stimulation capacity of IUdR induced C-type virus activation in our test conditions.

摘要

当用化学致癌物处理MLg小鼠细胞时，在微粒体酶和还原型辅酶II存在的情况下，经5-碘脱氧尿苷（IUdR）处理后，内源性C型病毒的诱导频率与仅用IUdR处理的培养物相比增加了近10倍。在对几种多环烃（包括致癌和非致癌产物）的初步筛选中，在我们的测试条件下，体内致癌性与IUdR诱导的C型病毒激活的刺激能力之间显然没有相关性。