Hessel L W, Vermeer B J, Polano M K, De Jonge H, De Pagter H A, Van Gent C M
Clin Chim Acta. 1976 Jun 15;69(3):405-16. doi: 10.1016/0009-8981(76)90112-1.
Blood lipid values, clinical data and effects of therapy are reported on 74 patients with hyperlipidemia and xanthomatosis. A natural subdivision into two groups was observed on the basis of low density lipoprotein lipid values: one corresponding to Frederickson's type II, characterized by elevated low density lipoproteins, tendinous xanthomata, absence of eruptive xanthomata and a high incidence of cardiovascular diseases and the other resembling Frederickson's type III, with elevated very low density lipoproteins, eruptive xanthomata, xanthomata striata palmaria, elevated cholesterol/triglyceride ratios in the very low density lipoproteins and irregular appearance of floating beta lipoproteins. The latter group consisted of 32 patients in whom cardiovascular symptoms were relatively rare, despite mean cholesterol levels of 500 mg/dl.
报告了74例高脂血症和黄瘤病患者的血脂值、临床数据及治疗效果。根据低密度脂蛋白血脂值可自然分为两组：一组对应弗雷德里克森II型，其特征为低密度脂蛋白升高、肌腱黄瘤、无疹性黄瘤以及心血管疾病高发；另一组类似弗雷德里克森III型，其特征为极低密度脂蛋白升高、疹性黄瘤、掌纹状黄瘤、极低密度脂蛋白中胆固醇/甘油三酯比值升高以及漂浮β脂蛋白外观不规则。后一组由32例患者组成，尽管平均胆固醇水平为500mg/dl，但心血管症状相对少见。
