南巴豆的抗菌二萜类化合物1. 哈德威克酸和3,4-裂环巴豆酸

Antimicrobial diterpenes of Croton sonderianus, 1. Hardwickic and 3,4-secotrachylobanoic acids.

作者信息

McChesney J D, Clark A M, Silveira E R

机构信息

Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University 38677.

出版信息

J Nat Prod. 1991 Nov-Dec;54(6):1625-33. doi: 10.1021/np50078a021.

DOI:10.1021/np50078a021

PMID:1812213

Abstract

The hexane-extracted resin of the roots of Croton sonderianus showed antimicrobial activity in standardized bioassays. Fractionation of the resin yielded two acid diterpenes, (-)-hardwickic acid [2] and the new 3,4-secotrachylobanoic acid [5] as major bioactive materials.

摘要

巴豆的根经己烷提取的树脂在标准化生物测定中显示出抗菌活性。对该树脂进行分馏得到两种酸性二萜，（-）-哈德威克酸[2]和新的3,4-裂克罗烷酸[5]作为主要生物活性物质。