HIRST G K
J Exp Med. 1949 Feb;89(2):223-32. doi: 10.1084/jem.89.2.223.
A substance (VHI) exists in human plasma which inhibits the agglutination of red cells by influenza virus and is distinct from influenza antibody. When plasma is fractionated by alcohol in the cold the VHI comes out mainly with a mixture of lipid-free alpha and beta globulins (fraction IV-4). On further fractionation the activity comes out with a fraction consisting mainly of beta(1) globulin (fraction IV-7). Boiling fraction IV-4 or IV-7 after considerable dilution brings about a large increase in the amount of VHI, much more than can be detected in the original plasma. A similar VHI has been extracted from the ghosts of fowl red cells.
人体血浆中存在一种物质(VHI),它能抑制流感病毒对红细胞的凝集作用,且与流感抗体不同。当血浆在低温下用酒精分级分离时,VHI主要与无脂质的α和β球蛋白混合物一起析出(IV - 4组分)。进一步分级分离时,活性物质与主要由β(1)球蛋白组成的一个组分一起析出(IV - 7组分)。将IV - 4或IV - 7组分在大量稀释后煮沸,会使VHI的量大幅增加,增加的量远超过原血浆中可检测到的量。已从鸡红细胞的细胞膜中提取出类似的VHI。