Takasu N, Sato S, Yamada T, Makiuchi M, Furihata R
Horm Metab Res. 1976 May;8(3):206-11. doi: 10.1055/s-0028-1093661.
PGE1 was equally effective in increasing 3H-cyclic AMP in normal and in toxic thyroids, whereas TSH was less effective but over a longer time in the toxic thyroids. Stimulation by a large second dose of TSH could not be elicited after prior stimulation by large doses of TSH. Similar results were obtained with regard to the effect of PGE1. However, stimulation by a large dose of PGE1 was still effective after the slices became refractory to TSH. Similarly, stimulation by a large dose of TSH was still effective after the slices became refractory to PGE1. It is suggested that the site and/or mode of action of TSH is quite different from that of PGE1.
前列腺素E1（PGE1）在正常甲状腺和毒性甲状腺中增加3H-环磷酸腺苷（3H-cyclic AMP）的效果相同，而促甲状腺激素（TSH）的效果较差，但在毒性甲状腺中作用时间更长。在大剂量TSH预先刺激后，无法引发第二次大剂量TSH的刺激。关于PGE1的作用也获得了类似结果。然而，在切片对TSH变得不应答后，大剂量PGE1的刺激仍然有效。同样，在切片对PGE1变得不应答后，大剂量TSH的刺激仍然有效。这表明TSH的作用位点和/或作用方式与PGE1有很大不同。
