Niederhoff H, Luthardt T, Wehinger H
Infection. 1976;4(2):90-3. doi: 10.1007/BF01638723.
A boy 13 year-old suffered an extremely severe and prolonged attack of hemorrhagic chickenpox with visceral involvement, the diagnosis being confirmed by isolation of varicella-zoster-virus (VZV). There was no other compromising disease. All preceding vaccinations including two against smallpox had been uneventful. The severity of the attack could not be ascribed to any persistent cellular or humoral immunodeficiency. The patient developed a good antibody response. The course of serological reactions to VZV infection was studied extensively using the different techniques of complement fixation and immunofluorescence for IgG, IgM, and IgA antibodies. Therapy was conducted cautiously using cytosine arabinoside (Ara-C) between the 10th and 17th day of disease; the temperature fell and VZV multiplication ceased, strongly suggesting a beneficial influence on the patient, who recovered completely.
一名13岁男孩患了极其严重且持续时间长的出血性水痘，并累及内脏，通过分离水痘-带状疱疹病毒（VZV）确诊。无其他并存疾病。之前包括两次天花疫苗接种在内的所有疫苗接种均顺利。此次发作的严重程度不能归因于任何持续性细胞或体液免疫缺陷。患者产生了良好的抗体反应。使用补体结合及免疫荧光检测IgG、IgM和IgA抗体的不同技术，广泛研究了对VZV感染的血清学反应过程。在病程第10天至第17天谨慎使用阿糖胞苷（Ara-C）进行治疗；体温下降，VZV增殖停止，有力地表明对患者有有益影响，患者完全康复。
