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相似文献

1
Suppression of polarity of insertion mutations in the gal operon and N mutations in bacteriophage lambda.抑制半乳糖操纵子中插入突变的极性和噬菌体λ中的N突变。
J Bacteriol. 1976 Jun;126(3):1108-12. doi: 10.1128/jb.126.3.1108-1112.1976.
2
Specificity of polarity suppression in E. coli: correction of defects in gene N, but not in gene Q, of phage lambda.
Mol Gen Genet. 1976 Oct 18;148(2):175-82. doi: 10.1007/BF00268383.
3
Suppression of polarity of insertion mutations within the gal operon of E. coli.
Mol Gen Genet. 1977 Mar 16;151(3):295-304. doi: 10.1007/BF00268793.
4
Release of polarity in Escherichia coli by gene N of phage lambda: termination and antitermination of transcription.噬菌体λ的N基因对大肠杆菌极性的释放：转录的终止与抗终止
Proc Natl Acad Sci U S A. 1974 Jun;71(6):2534-8. doi: 10.1073/pnas.71.6.2534.
5
Multiple regulator gene control of the galactose operon in Escherichia coli K-12.大肠杆菌K-12中半乳糖操纵子的多调节基因控制
J Bacteriol. 1972 Jun;110(3):1089-99. doi: 10.1128/jb.110.3.1089-1099.1972.
6
Effects of dimethylsulfoxide on the E. coli gal operon and on bacteriophage lambda in vivo.二甲基亚砜对大肠杆菌半乳糖操纵子及λ噬菌体的体内效应。
Cell. 1974 Sep;3(1):39-46. doi: 10.1016/0092-8674(74)90035-x.
7
Suppression of polarity in the gal operon by ultraviolet irradiation.紫外线照射对半乳糖操纵子极性的抑制作用。
J Bacteriol. 1980 Dec;144(3):1205-7. doi: 10.1128/jb.144.3.1205-1207.1980.
8
Galactose-specific messenger ribonucleic acid contents in Escherichia coli: effect of inducer, gene dosage and galactose genotype.大肠杆菌中半乳糖特异性信使核糖核酸的含量：诱导物、基因剂量和半乳糖基因型的影响。
Cytobios. 1975;12(45):19-29.
9
Characterization of strong polar mutations in a region immediately adjacent to the L-arabinose operator in Escherichia coli B-r.大肠杆菌B-r中紧邻L-阿拉伯糖操纵子区域的强极性突变的特征分析
J Bacteriol. 1972 Aug;111(2):383-91. doi: 10.1128/jb.111.2.383-391.1972.
10
Isolation and characterization of conditional lethal mutants of Escherichia coli defective in transcription termination factor rho.转录终止因子rho缺陷的大肠杆菌条件致死突变体的分离与鉴定。
Proc Natl Acad Sci U S A. 1976 Jun;73(6):1959-63. doi: 10.1073/pnas.73.6.1959.

引用本文的文献

1
Overexpression of an mRNA dependent on rare codons inhibits protein synthesis and cell growth.依赖稀有密码子的mRNA过表达会抑制蛋白质合成和细胞生长。
J Bacteriol. 1996 May;178(10):2926-33. doi: 10.1128/jb.178.10.2926-2933.1996.
2
Suppression of polarity in the gal operon by ultraviolet irradiation.紫外线照射对半乳糖操纵子极性的抑制作用。
J Bacteriol. 1980 Dec;144(3):1205-7. doi: 10.1128/jb.144.3.1205-1207.1980.
3
Relation between UV suppression of polarity in phi X174 and UV sensitivity of rho mutants.φX174中紫外线对极性的抑制与rho突变体的紫外线敏感性之间的关系。
J Virol. 1981 Mar;37(3):955-62. doi: 10.1128/JVI.37.3.955-962.1981.
4
Autoregulation of the rho gene of Escherichia coli K-12.大肠杆菌K-12 rho基因的自动调节
Mol Gen Genet. 1984;193(2):210-3. doi: 10.1007/BF00330669.
5
Antitermination of transcription from an Escherichia coli ribosomal RNA promoter.来自大肠杆菌核糖体RNA启动子的转录抗终止作用。
Proc Natl Acad Sci U S A. 1984 Nov;81(21):6789-93. doi: 10.1073/pnas.81.21.6789.
6
Efficient read-through of Tn9 and IS1 by RNA polymerase molecules that initiate at rRNA promoters.由在rRNA启动子处起始的RNA聚合酶分子对Tn9和IS1进行高效通读。
J Bacteriol. 1983 Feb;153(2):672-84. doi: 10.1128/jb.153.2.672-684.1983.
7
Polarity in the glnA operon: suppression of the reg- phenotype by rho mutations.谷氨酰胺合成酶操纵子中的极性：rho突变对reg-表型的抑制作用。
J Bacteriol. 1982 Jun;150(3):1314-21. doi: 10.1128/jb.150.3.1314-1321.1982.
8
Expression of proteins essential for IS1 transposition: specific binding of InsA to the ends of IS1.IS1转座所需蛋白质的表达：InsA与IS1末端的特异性结合。
EMBO J. 1987 Oct;6(10):3163-9. doi: 10.1002/j.1460-2075.1987.tb02627.x.
9
Efficient suppression of the requirement for N function of bacteriophage lambda by a Rho-defective E.coli suA mutant.Rho缺陷型大肠杆菌suA突变体对噬菌体λ N功能需求的有效抑制
Mol Gen Genet. 1976 Oct 18;148(2):171-3. doi: 10.1007/BF00268382.
10
Expression of the cloned uvrB gene of Escherichia coli: dependency on nonsense suppressors.大肠杆菌克隆的uvrB基因的表达：对无义抑制子的依赖性。
J Bacteriol. 1979 Jul;139(1):48-53. doi: 10.1128/jb.139.1.48-53.1979.

本文引用的文献

1
Bacterial mutants able to partly suppress the effect of N mutations in bacteriophage lambda.能够部分抑制λ噬菌体N突变效应的细菌突变体。
Mol Gen Genet. 1975;136(2):167-80. doi: 10.1007/BF00272037.
2
The nature of the gal3 mutation of Escherichia coli.大肠杆菌gal3突变的性质。
Mol Gen Genet. 1975;136(3):233-42. doi: 10.1007/BF00334018.
3
RESTORATION OF OPERON ACTIVITY BY SUPPRESSORS.通过抑制子恢复操纵子活性
Biochim Biophys Acta. 1963 Sep 17;76:162-4.
4
Sensitive mutants of bacteriophage lambda.噬菌体λ的敏感突变体
Virology. 1961 May;14:22-32. doi: 10.1016/0042-6822(61)90128-3.
5
Isolation and characterization of new sus (amber) mutants of bacteriophage lambda.噬菌体λ新sus（琥珀）突变体的分离与鉴定
Mutat Res. 1967 Nov-Dec;4(6):735-41. doi: 10.1016/0027-5107(67)90082-6.
6
New polarity suppressors in Escherichia coli: suppression and messenger RNA stability.大肠杆菌中的新型极性抑制子：抑制作用与信使核糖核酸稳定性
Proc Natl Acad Sci U S A. 1971 Dec;68(12):2962-6. doi: 10.1073/pnas.68.12.2962.
7
Phosphoglucomutase mutants of Escherichia coli K-12.大肠杆菌K-12的磷酸葡萄糖变位酶突变体
J Bacteriol. 1971 Nov;108(2):621-6. doi: 10.1128/jb.108.2.621-626.1971.
8
The galactose operon of E. coli K-12. I. Structural and pleiotropic mutations of the operon.大肠杆菌K-12的半乳糖操纵子。I. 操纵子的结构和多效性突变
Genetics. 1969 Jun;62(2):231-47. doi: 10.1093/genetics/62.2.231.
9
Altered reading of genetic signals fused to the N operon of bacteriophage lambda: genetic evidence for modification of polymerase by the protein product of the N gene.
J Mol Biol. 1974 Oct 15;89(1):33-48. doi: 10.1016/0022-2836(74)90161-2.
10
Release of polarity in Escherichia coli by gene N of phage lambda: termination and antitermination of transcription.噬菌体λ的N基因对大肠杆菌极性的释放：转录的终止与抗终止
Proc Natl Acad Sci U S A. 1974 Jun;71(6):2534-8. doi: 10.1073/pnas.71.6.2534.

抑制半乳糖操纵子中插入突变的极性和噬菌体λ中的N突变。

Suppression of polarity of insertion mutations in the gal operon and N mutations in bacteriophage lambda.

作者信息

Reyes O, Gottesman M, Adhya S

出版信息

J Bacteriol. 1976 Jun;126(3):1108-12. doi: 10.1128/jb.126.3.1108-1112.1976.

DOI:10.1128/jb.126.3.1108-1112.1976
PMID:181361
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC233132/
Abstract

Bacterial mutations (psuA and psu) known for their ability to suppress the polarity on nonsense mutations are shown to suppress the polarity of certain insertion mutations in the gal operon. The short insertion, IS1 (800 nucleotide pairs), is about 15 to 50% suppressed, whereas longer insertions, IS2 (1,400 nucleotide pairs), and IS3 (1,200 nucleotide pairs), are not. Some of the polarity suppressor mutations (psu-1, psu-2, and psu-3) are at least partially permissive for N-gene mutations (N7 and N53) of bacteriophage lambda, suggesting a relationship between natural and mutational polar signals. That this relationship may be complex is indicated by the fact that other suppressor mutations, effective in suppressing nonsense or insertion polarity, fail entirely to permit the growth of lambda N mutants.

摘要

已知具有抑制无义突变极性能力的细菌突变（psuA和psu）被证明可抑制gal操纵子中某些插入突变的极性。短插入序列IS1（800个核苷酸对）约有15%至50%被抑制，而较长的插入序列IS2（1400个核苷酸对）和IS3（1200个核苷酸对）则未被抑制。一些极性抑制突变（psu - 1、psu - 2和psu - 3）对噬菌体λ的N基因突变（N7和N53）至少部分允许，这表明天然极性信号与突变极性信号之间存在关联。其他抑制突变虽能有效抑制无义或插入极性，但完全不能使λ N突变体生长，这一事实表明这种关系可能很复杂。