Valenta L J
J Clin Endocrinol Metab. 1976 Aug;43(2):466-9. doi: 10.1210/jcem-43-2-466.
Tissues from normal thyroid, euthyroid multinodular goiter, toxic goiter, Hashimoto's thyroiditis, thyroid adenoma, and carcinoma were examined for their content of deoxyribonucleic acid (DNA), thyroid peroxidase activity (TPA), thyroglobulin (TG), and adenosine 3',5'-cyclic monophosphate (cAMP). Compared with normal thyroids DNA was increased in the neoplastic tissues and decreased in euthyroid multinodular goiter. Quantitative changes of thyroglobulin were observed, especially in the thyroid tumors, and, in one case, immunoreactive 4S thyroglobulin-like protein was identified in the absence of 19S. TPA was grossly elevated in toxic goiter. This may be of significance in the pathogenesis of Graves' disease. TPA remained elevated even after adequate control of hyperthyroidism by preoperative PTU treatment. The cyclic AMP concentration in toxic goiter did not statistically differ from normal. This may indicate that extrathyroidal regulatory factors have a lesser role in the genesis and perpetuation of Graves' disease than otherwise believed. Cyclic AMP is known to exert a negative influence on tissue growth, and low concentrations in neoplasia have been reported. The values in the thyroid tumors studied were elevated, requiring further explanation.
对来自正常甲状腺、甲状腺功能正常的多结节性甲状腺肿、毒性甲状腺肿、桥本甲状腺炎、甲状腺腺瘤和癌的组织进行了脱氧核糖核酸（DNA）含量、甲状腺过氧化物酶活性（TPA）、甲状腺球蛋白（TG）和腺苷3',5'-环磷酸（cAMP）的检测。与正常甲状腺相比，肿瘤组织中的DNA增加，而甲状腺功能正常的多结节性甲状腺肿中的DNA减少。观察到甲状腺球蛋白的定量变化，尤其是在甲状腺肿瘤中，并且在一例中，在缺乏19S甲状腺球蛋白的情况下鉴定出免疫反应性4S甲状腺球蛋白样蛋白。毒性甲状腺肿中的TPA显著升高。这可能在格雷夫斯病的发病机制中具有重要意义。即使术前用丙硫氧嘧啶（PTU）治疗充分控制甲亢后，TPA仍保持升高。毒性甲状腺肿中的环磷酸腺苷浓度与正常情况在统计学上无差异。这可能表明甲状腺外调节因子在格雷夫斯病的发生和持续存在中的作用比其他认为的要小。已知环磷酸腺苷对组织生长有负面影响，并且有报道称肿瘤中的浓度较低。所研究的甲状腺肿瘤中的值升高，需要进一步解释。
