Chen Z, Qing D, Liu Y, Xie B
Hua Xi Yi Ke Da Xue Xue Bao. 1991 Sep;22(4):387-90.
Experiments were performed on 14 rabbits locally anesthetized with procaine. Both vagus nerves were cut. The animals were immobilized with gallamine trithiodide and maintained by artificial ventilation. The effects of electrical stimulation of "Renzhong" area on arterial blood pressure and heart rate were observed before and after microinjection of kainic acid (KA) into rostral ventrolateral medulla (RVL). Electrical stimulation of "Renzhong" area could elicit a very marked increase in arterial blood pressure, before microinjection of KA into RVL. Bilateral microinjection of KA (0.5 microgram, an excitotoxin) into RVL could essentially abolish the pressor effect of stimulation of "Renzhong" area. However, bilateral microinjection of NS into RVL showed no effects on the pressor effect of stimulation of "Renzhong" area. These results suggest that RVL plays a key role in the pressor effect of "Renzhong" area stimulation.
实验在14只经普鲁卡因局部麻醉的家兔身上进行。双侧迷走神经被切断。动物用三碘季铵酚制动，并通过人工通气维持。在向延髓头端腹外侧区（RVL）微量注射海人酸（KA）前后，观察电刺激“人中”区对动脉血压和心率的影响。在向RVL微量注射KA之前，电刺激“人中”区可引起动脉血压非常显著的升高。向RVL双侧微量注射KA（0.5微克，一种兴奋性毒素）可基本消除刺激“人中”区的升压效应。然而，向RVL双侧微量注射生理盐水对刺激“人中”区的升压效应无影响。这些结果表明，RVL在刺激“人中”区的升压效应中起关键作用。
