Wang H X, Chen M C
Institute of Basic Medical Sciences, Beijing.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1990 Jun;12(3):193-7.
The experiments were performed on 51 cats of either sex weighing 1.8-2.4 kg to investigate the role of the ventrolateral medulla in the pressor response elicited by stimulation of central ends of abdominal vagi. We observed that both the stimulation of the central ends of abdominal vagi and occlusion of one carotid artery increased the blood pressure by 17.4 +/- 1.6 mmHg (n = 51, P less than 0.01) and 14.7 +/- 1.9 mmHg (n = 19, P less than 0.01) respectively; blockade of the caudal ventrolateral medulla or trapezoid bodies with lidocaine had little effect on blood pressure and the pressor response, but blockade of the rostral ventrolateral medulla with either lidocaine or kainic acid could cause profound depression, and even abolition, of the pressor response. Moreover, application of atropine and phentolamine to the RVL severely inhibited the abdominal vagal pressor response without affecting the baroreceptor reflex. Taken together, we conclude that the RVL is a very important relay in the pathway of the abdominal vagal pressor response in which the adrenergic and cholinergic mechanisms may be involved in the RVL, and it seems that the pressor response pathway is independent of that of the baroreceptor reflex in the RVL.
实验在51只体重为1.8 - 2.4千克的雌雄猫身上进行，以研究延髓腹外侧在刺激腹侧迷走神经中枢端所引发的升压反应中的作用。我们观察到，刺激腹侧迷走神经中枢端和阻断一侧颈动脉分别使血压升高17.4±1.6毫米汞柱（n = 51，P<0.01）和14.7±1.9毫米汞柱（n = 19，P<0.01）；用利多卡因阻断延髓尾端腹外侧或梯形体对血压和升压反应影响不大，但用利多卡因或 kainic 酸阻断延髓头端腹外侧可导致升压反应显著抑制甚至消失。此外，向延髓头端腹外侧应用阿托品和酚妥拉明可严重抑制腹侧迷走神经升压反应，而不影响压力感受器反射。综上所述，我们得出结论，延髓头端腹外侧是腹侧迷走神经升压反应通路中一个非常重要的中继站，其中肾上腺素能和胆碱能机制可能在延髓头端腹外侧起作用，并且升压反应通路似乎在延髓头端腹外侧独立于压力感受器反射通路。
