抗癌药物对白细胞介素-3体外释放的影响。
Effect of anticancer drugs on the release of interleukin-3 in vitro.
作者信息
Hasan S I, Turk J L
机构信息
Department of Pathology, Royal College of Surgeons of England, London, U.K.
出版信息
Int J Immunopharmacol. 1991;13(8):1177-85. doi: 10.1016/0192-0561(91)90169-8.
In this study several anticancer drugs were tested for their effect on the release of interleukin-3 (IL-3) from concanavalin A (Con A) stimulated mouse splenocytes in vitro. When Adriamycin or vincristine were added to the cultures at non-cytotoxic concentrations, the release of IL-3 was inhibited. However, bleomycin, FK156, FK565 and 4-OOH-cyclophosphamide (the in vitro active analogue of the anticancer and immunosuppressive drug cyclophosphamide) did not alter the release of IL-3 under the same conditions. It was confirmed that cyclosporin A inhibited the release of IL-3 in the same experimental system.
在本研究中，测试了几种抗癌药物对体外伴刀豆球蛋白A（Con A）刺激的小鼠脾细胞释放白细胞介素-3（IL-3）的影响。当以非细胞毒性浓度将阿霉素或长春新碱添加到培养物中时，IL-3的释放受到抑制。然而，博来霉素、FK156、FK565和4-羟基环磷酰胺（抗癌和免疫抑制药物环磷酰胺的体外活性类似物）在相同条件下并未改变IL-3的释放。已证实在相同的实验系统中，环孢素A抑制IL-3的释放。
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