体内使用博来霉素和阿霉素治疗对大鼠白细胞介素-2释放的增强作用。
Enhancement of interleukin-2 release in rats by treatment with bleomycin and adriamycin in vivo.
作者信息
Abdul Hamied T A, Turk J L
机构信息
Department of Pathology, Royal College of Surgeons of England, UK.
出版信息
Cancer Immunol Immunother. 1987;25(3):245-9. doi: 10.1007/BF00199154.
Abstract
Spleen cells from rats previously injected with bleomycin (10 mg/kg) or Adriamycin (1 mg/kg) were able to release higher levels of interleukin-2 (IL-2) than cells from untreated animals. The difference in IL-2 release was detected after the cells were exposed to a suboptimal dose of concanavalin A (0.5 micrograms/ml) for 24 h. By cytofluorimetry, these drugs did not change the proportion of W3/25+ (helper) or OX-8+ (suppressor) T-cell subsets. In contrast, the immunosuppressive drug cyclophosphamide inhibited the IL-2 release from spleen cells under the same conditions. It is suggested that some anti-cancer antibiotics may be able to enhance the release of IL-2 while other cytotoxic drugs with more immunosuppressive potential could inhibit the release of this mediator.
摘要
先前注射博来霉素（10毫克/千克）或阿霉素（1毫克/千克）的大鼠的脾细胞，与未处理动物的细胞相比，能够释放更高水平的白细胞介素-2（IL-2）。在细胞暴露于次优剂量的刀豆球蛋白A（0.5微克/毫升）24小时后，检测到IL-2释放的差异。通过细胞荧光测定法，这些药物并未改变W3/25 +（辅助性）或OX-8 +（抑制性）T细胞亚群的比例。相比之下，免疫抑制药物环磷酰胺在相同条件下抑制脾细胞释放IL-2。有人提出，一些抗癌抗生素可能能够增强IL-2的释放，而其他具有更强免疫抑制潜力的细胞毒性药物可能会抑制这种介质的释放。
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