抗癌药物对体外γ干扰素释放的影响。
Effect of anticancer drugs on the release of interferon gamma in vitro.
作者信息
Ahmed K, van der Meide P H, Turk J L
机构信息
Department of Pathology, Royal College of Surgeons of England, London, U.K.
出版信息
Cancer Immunol Immunother. 1989;30(4):213-8. doi: 10.1007/BF01665007.
Some conventional and experimental anti-cancer drugs were tested for their effect on concanavalin-A-induced interferon gamma release from rat splenocytes in vitro. When 2.5 x 10(6) rat splenocytes/ml, stimulated with 1 microgram/ml concanavalin A, were incubated with various non-cytotoxic doses of the vinca alkaloid vincristine, there was an inhibition of the release of interferon gamma in culture supernatants. The antitumour antibiotics bleomycin and Adriamycin, alkylating agents 4-hydroperoxycyclophosphamide and mafosfamide, and the immunoactive peptides FK156 and FK565 did not affect the release of interferon gamma under similar conditions. However, cyclosporin A, in similar experiments, markedly inhibited the release of interferon gamma.
对一些传统和实验性抗癌药物进行了测试，以观察它们对体外伴刀豆球蛋白A诱导的大鼠脾细胞释放γ干扰素的影响。当每毫升2.5×10⁶个大鼠脾细胞，用1微克/毫升伴刀豆球蛋白A刺激后，与各种无细胞毒性剂量的长春花生物碱长春新碱一起孵育时，培养上清液中γ干扰素的释放受到抑制。在类似条件下，抗肿瘤抗生素博来霉素和阿霉素、烷化剂4-氢过氧环磷酰胺和马磷酰胺以及免疫活性肽FK156和FK565均不影响γ干扰素的释放。然而，在类似实验中，环孢素A显著抑制了γ干扰素的释放。
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