抗癌药物对体外肿瘤坏死因子释放的影响。
Effect of anticancer drugs on the release of tumour necrosis factor in vitro.
作者信息
Hasan S I, Ahmed K, Turk J L
机构信息
Royal College of Surgeons of England, London, UK.
出版信息
Cancer Immunol Immunother. 1990;30(6):363-6. doi: 10.1007/BF01786886.
The anticancer drugs Adriamycin, bleomycin, vincristine, 4-hydroperoxycyclophosphamide, FK156 and FK565 and the immunosuppressive drug cyclosporin-A were tested for their effect on lipopolysaccharide-induced tumour necrosis factor-alpha (TNF) release from rat peritoneal exudate cells in vitro. FK565 resulted in a marked enhancement of TNF release when added to cultures at doses of 1 microgram/ml and 10 micrograms/ml. However, FK156, Adriamycin, bleomycin, 4-hydroperoxycyclophosphamide, vincristine and cyclosporin A did not affect the release of TNF under the same conditions. Puromycin inhibited the release of TNF in the same system at non-cytotoxic doses of 1 microgram/ml and 10 micrograms/ml.
对阿霉素、博来霉素、长春新碱、4-氢过氧环磷酰胺、FK156、FK565等抗癌药物以及免疫抑制药物环孢素A进行了测试，以观察它们对体外培养的大鼠腹腔渗出细胞中脂多糖诱导的肿瘤坏死因子-α（TNF）释放的影响。当以1微克/毫升和10微克/毫升的剂量添加到培养物中时，FK565导致TNF释放显著增强。然而，在相同条件下，FK156、阿霉素、博来霉素、4-氢过氧环磷酰胺、长春新碱和环孢素A对TNF的释放没有影响。嘌呤霉素在1微克/毫升和10微克/毫升的非细胞毒性剂量下抑制了同一系统中TNF的释放。
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