Baltissen R, Teppe M, Boucsein W, Fehm-Wolfsdorf G, Fehm H L
University of Wuppertal, FRG.
Peptides. 1991 Nov-Dec;12(6):1393-8. doi: 10.1016/0196-9781(91)90225-e.
Effects of arginine-vasopressin (AVP) on the habituation of the orienting reaction and response to stimulus mismatch were investigated in a between-group design with 40 healthy male volunteers using skin conductance and heart rate responses as dependent measures. Twenty-one 1000 Hz tones of 90 dB(A) intensity and 2 s duration were presented with alternating intervals of 20 and 140 s. Stimulus mismatch responses were analyzed to the tones after the long intervals and to a change of the interval duration. The expected prevention of habituation as an indicator of a general stimulus-related increase of phasic arousal under AVP could not be confirmed. There were no differences between the AVP and the placebo group in the skin conductance and heart rate responses. The interval change did not provoke a dishabituation reaction, but responses to the tones after the long intervals were reliably enhanced. However, AVP did not increase the reaction to stimulus mismatch. It is concluded that autonomic indicators of the habituation of the OR remain unaffected by AVP.
采用组间设计，以40名健康男性志愿者为研究对象，以皮肤电导率和心率反应作为因变量指标，研究了精氨酸加压素（AVP）对定向反应习惯化和对刺激不匹配反应的影响。以90分贝（A）强度、2秒时长的21个1000赫兹纯音进行呈现，间隔时间交替为20秒和140秒。分析了长间隔后的纯音以及间隔时长变化后的刺激不匹配反应。预期的作为AVP作用下阶段性唤醒普遍与刺激相关增加指标的习惯化预防未得到证实。AVP组和安慰剂组在皮肤电导率和心率反应方面没有差异。间隔变化未引发去习惯化反应，但长间隔后的纯音反应得到了可靠增强。然而，AVP并未增加对刺激不匹配的反应。得出的结论是，定向反应习惯化的自主指标不受AVP影响。
