Andersen Klaus Ejner, Andersen Flemming
Department of Dermatology, Odense University Hospital, University of Southern Denmark, Sdr. Boulevard 29, DK-5000 Odense C, Denmark.
Contact Dermatitis. 2008 Jan;58(1):28-31. doi: 10.1111/j.1600-0536.2007.01252.x.
Assessing the quality of patch test preparations continues to be a challenge. 2 parameters, the reaction index (RI) and positivity ratio (PR), have been proposed as quality indicators by the Information Network of Departments of Dermatology (IVDK). The value of these statistics has not been examined by others.
We calculated the RI and PR for the 24 TRUE test allergens in 7635 patients with consecutive eczema tested at the Department of Dermatology, Odense University Hospital over a 15-year period, and data for 7 selected standard allergens were compared with corresponding data from the original IVDK papers.
At our patch test laboratory, RI's are lower, even negative, and the PR's are considerably lower than the IVDK results. The most likely explanation is a difference in reading/scoring tradition between the different departments of the IVDK and our department. Calculation of RI's and PR's for patch test allergens is of limited value as a measure of quality of the patch test materials, because it predominantly reflects differences in scoring and reading of patch test reactions. Further, questionable reactions (+?) may be clinically relevant and very important for the individual patient. Focus on standardization of patch test materials, patch test technique, and reading of patch test reactions is mandatory.
评估斑贴试验制剂的质量仍然是一项挑战。皮肤科部门信息网络（IVDK）提出了两个参数，即反应指数（RI）和阳性率（PR）作为质量指标。其他人尚未检验这些统计数据的价值。
我们计算了15年间在欧登塞大学医院皮肤科连续接受检测的7635例湿疹患者中24种TRUE试验变应原的RI和PR，并将7种选定标准变应原的数据与IVDK原始论文中的相应数据进行了比较。
在我们的斑贴试验实验室，RI较低，甚至为阴性，PR也远低于IVDK的结果。最可能的解释是IVDK不同部门与我们部门在判读/评分传统上存在差异。计算斑贴试验变应原的RI和PR作为斑贴试验材料质量的衡量指标价值有限，因为它主要反映了斑贴试验反应评分和判读的差异。此外，可疑反应（+?）可能具有临床相关性，对个体患者非常重要。必须注重斑贴试验材料、斑贴试验技术以及斑贴试验反应判读的标准化。
