Haddad Robert, Annino Donald, Tishler Roy B
Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.
Dent Clin North Am. 2008 Jan;52(1):1-17, vii. doi: 10.1016/j.cden.2007.10.005.
This article focuses on squamous cell carcinoma of the head and neck (SCCHN), the most common malignancy of the head and neck area. Early detection limits morbidity of treatment and increases the chances of a cure. The treatment of SCCHN is often multidisciplinary in nature and provides a model for how multimodality therapy may be applied for optimal patient management. The role of surgery in SCCHN is continually undergoing evolution, and the surgeon's role in the multidisciplinary treatment of head and neck cancers has changed as more cancers are being treated by chemoradiotherapy. Salvage surgery has become more common, and with it the increased challenges in managing metastatic disease to neck nodes as well as managing failure of organ preservation treatments. Surgeons continue to develop and refine reconstruction techniques to optimize cosmetic and functional outcomes.
本文聚焦于头颈部鳞状细胞癌(SCCHN),这是头颈部区域最常见的恶性肿瘤。早期检测可限制治疗的发病率并增加治愈的机会。SCCHN的治疗本质上通常是多学科的,并为如何应用多模式疗法实现最佳患者管理提供了一个范例。手术在SCCHN中的作用不断演变,随着越来越多的癌症采用放化疗进行治疗,外科医生在头颈部癌症多学科治疗中的角色也发生了变化。挽救性手术变得更加普遍,随之而来的是在管理颈部淋巴结转移性疾病以及处理器官保留治疗失败方面面临的挑战增加。外科医生不断开发和完善重建技术,以优化美容和功能效果。