Pieri C, Falasca M, Moroni F, Recchioni R, Marcheselli F
Cytology Center, Gerontological Research Department of INRCA, Ancona, Italy.
Biochem Int. 1991 Nov;25(4):631-8.
The influence of membrane microviscosity on 5'-nucleotidase activity has been investigated on liver plasma membrane preparations from rats during aging and following diet restriction. In addition the microviscosity of membranes from old rats was changed in vitro by the Active Lipids. During aging the membrane microviscosity increased progressively and in parallel the activity of 5'-nucleotidase decreased. Diet restriction was able to slow down the modification of both parameters. The experiment performed with the Active Lipids further supports that membrane microviscosity modulated the enzyme activity.
在衰老过程中以及饮食限制后,对大鼠肝细胞膜制剂研究了膜微粘度对5'-核苷酸酶活性的影响。此外,活性脂质在体外改变了老年大鼠细胞膜的微粘度。在衰老过程中,膜微粘度逐渐增加,同时5'-核苷酸酶的活性降低。饮食限制能够减缓这两个参数的变化。用活性脂质进行的实验进一步支持膜微粘度调节酶活性这一观点。