Hamdorf G, Cervós-Navarro J
Institute of Neuropathology, Free University of Berlin, Fed. Rep. of Germany.
Arzneimittelforschung. 1991 Dec;41(12):1206-10.
Eighty Wistar rats were maintained under conditions of chronic hypoxic for a period of 5 months. After gradual adaptation to the reduced oxygen content of the inhaled air, animals were kept on the levels of 15, 12, 10 and 7 vol% O2 and their behaviour in an open field was observed. One group of 40 animals received CDP-choline (cytidine diphosphate choline, Somazina; CAS 1477-47-0) at a dose of 100 mg/kg body weight in their food. Hypoxia-induced behavioural deteriorations were partly mitigated by this substance. Therapeutic application of CDP-choline was more effective than prophylactic administration. The efficiency of CDP-choline decreased after prolonged application. Under conditions of extreme hypoxia CDP-choline exhibited a life prolonging effect.
80只Wistar大鼠在慢性缺氧条件下饲养5个月。在逐渐适应吸入空气中降低的氧含量后，将动物置于氧含量为15%、12%、10%和7%（体积分数）的环境中，并观察它们在旷场中的行为。一组40只动物在其食物中接受剂量为100mg/kg体重的胞磷胆碱（胞苷二磷酸胆碱，索马西纳；CAS 1477-47-0）。该物质部分减轻了缺氧引起的行为恶化。胞磷胆碱的治疗应用比预防性给药更有效。长期应用后胞磷胆碱的效果降低。在极端缺氧条件下，胞磷胆碱表现出延长寿命的作用。
