Hamdorf G, Cervós-Navarro J, Müller R
Institute of Neuropathology, Free University of Berlin, Fed. Rep. of Germany.
Arzneimittelforschung. 1992 Apr;42(4):421-4.
36 Wistar rats were kept in chronic hypoxic hypoxia of 7 vol % of oxygen in 2 experiments over a period of 6 months, other 36 served as controls. Half of the animals of each group received cytidine diphosphate choline (CDP-choline, citicoline, Somazina; CAS 987-78-0) at a dose of 100 mg/kg body weight in the liquid food. Animals in chronic hypoxia without application of CDP-choline developed pathological symptoms and began to die after 19 to 23 weeks in hypoxia. Rats that received CDP-choline developed less prominent pathological symptoms and died later or remained alive until the end of the experiment. Under conditions of extreme hypoxia CDP-choline exhibited a life-prolonging effect.
在两项实验中，将36只Wistar大鼠置于氧气含量为7%的慢性低氧环境中6个月，另外36只作为对照。每组动物的一半在流质食物中接受剂量为100mg/kg体重的胞二磷胆碱（CDP - 胆碱、西替考林、索马西纳；CAS 987 - 78 - 0）。未应用CDP - 胆碱的慢性低氧动物出现病理症状，并在低氧环境中19至23周后开始死亡。接受CDP - 胆碱的大鼠出现的病理症状不那么明显，死亡时间较晚，或者存活到实验结束。在极端低氧条件下，CDP - 胆碱表现出延长生命的作用。
