Hamdorf G, Cervós-Navarro J
Institute of Neuropathology, Free University of Berlin, Germany.
Arzneimittelforschung. 1990 May;40(5):519-22.
48 Wistar rats were maintained over a period of 103 days while the oxygen content of the air was continuously reduced. Their behaviour in an open-field was observed at each step of oxygen deficiency (15, 12, 10, 8 and 7% O2 inspiratory). One group (24 animals) was given CDP-choline (cytidine diphosphate choline, Somazina) at a dose of 100 mg/kg body weight administered by addition to the food. Behavioral reactions indicative of deterioration in vigilance were recorded under hypoxic conditions. CDP-choline showed a protective effect increasing vigilance under mild (15% O2) hypoxia, indicating the possibility of treatment of patients with cerebral syndromes secondary to hypoxia.
48只Wistar大鼠在103天的时间里持续处于空气含氧量不断降低的环境中。在缺氧的每个阶段（吸入氧气含量分别为15%、12%、10%、8%和7%）观察它们在旷场中的行为。一组（24只动物）通过在食物中添加剂量为100mg/kg体重的胞二磷胆碱（CDP - 胆碱，索马西纳）。在缺氧条件下记录表明警觉性下降的行为反应。胞二磷胆碱在轻度（15%氧气）缺氧时显示出提高警觉性的保护作用，表明治疗缺氧继发脑综合征患者具有可能性。
