口腔未分化高级别多形性肉瘤：一例报告。

Oral undifferentiated high-grade pleomorphic sarcoma: report of a case.

作者信息

Alfredo Edson, de Pádua Joubert Magalhães, Vicentini Eduardo Luis, Marchesan Melissa Andreia, Comelli Lia Raphael Carlos, da Cruz Perez Danyel Elias, Silva-Sousa Yara Teresinha Corrêa

机构信息

School of Dentistry, University of Ribeirao Preto, Ribeirao Preto and São Paulo, Brazil.

出版信息

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Jan;105(1):e37-40. doi: 10.1016/j.tripleo.2007.07.023.

DOI:10.1016/j.tripleo.2007.07.023

PMID:18155600

Abstract

The current World Health Organization classification considers the existence of an undifferentiated unclassifiable category of pleomorphic sarcomas, defined as a group of pleomorphic high-grade sarcomas. Undifferentiated high-grade pleomorphic sarcoma represents about 5% of all soft tissue sarcomas in adults and occurs more commonly in the extremities. In the oral cavity, undifferentiated pleomorphic sarcoma is extremely rare. We report a case of undifferentiated high-grade pleomorphic sarcoma located in the floor of the mouth in a man 56 years old. Microscopically, spindle-shaped cells with accented pleomorphism arranged in a storiform pattern, several bizarre giant cells, and frequent atypical mitoses were observed. The tumor cells were positive only for vimentin, with focal positivity for CD68. The patient was treated by surgery and postoperative radiation therapy, and after 25 months, no recurrence was observed.

摘要

世界卫生组织目前的分类认为存在一种未分化的不可分类的多形性肉瘤类别，定义为一组多形性高级别肉瘤。未分化高级别多形性肉瘤约占成人所有软组织肉瘤的5%，更常见于四肢。在口腔中，未分化多形性肉瘤极为罕见。我们报告一例位于一名56岁男性口腔底部的未分化高级别多形性肉瘤病例。显微镜下，观察到梭形细胞，多形性明显，呈车辐状排列，有多个怪异的巨细胞，且有频繁的非典型有丝分裂。肿瘤细胞仅波形蛋白阳性，CD68呈局灶性阳性。该患者接受了手术及术后放射治疗，25个月后未观察到复发。