Xu Xianfeng M, Meier Iris
Department of Plant Cellular and Molecular Biology, The Ohio State University, Columbus, OH 43210, USA.
Trends Plant Sci. 2008 Jan;13(1):20-7. doi: 10.1016/j.tplants.2007.12.001. Epub 2007 Dec 21.
The nuclear pore complex is the gateway of macromolecular trafficking between the nucleus and the cytoplasm. Although its composition is well characterized in yeast and mammalian systems, little is known about the plant nuclear pore. Several recent reports describe complex whole-organism phenotypes based on mutations in plant nucleoporins. The pathways affected include plant-microbe interactions, auxin response, cold-stress tolerance and flowering-time regulation. The effects are probably based, at least in part, on changes in protein import and/or RNA export (including regulatory small RNAs). Here, we review these new findings while comparing and contrasting them with what is known about nucleoporin functions from non-plant organisms, including nucleoporin activities not linked to nucleocytoplasmic transport.
核孔复合体是细胞核与细胞质之间大分子运输的通道。尽管其组成在酵母和哺乳动物系统中已得到充分表征，但对于植物核孔却知之甚少。最近的几份报告描述了基于植物核孔蛋白突变的复杂的全生物体表型。受影响的途径包括植物与微生物的相互作用、生长素反应、耐冷胁迫和开花时间调控。这些影响可能至少部分基于蛋白质输入和/或RNA输出（包括调节性小RNA）的变化。在这里，我们回顾这些新发现，并将它们与已知的非植物生物体核孔蛋白功能进行比较和对比，包括与核质运输无关的核孔蛋白活性。
