Mak Tippi K, Mangtani Punam, Leese Jane, Watson John M, Pfeifer Dina
Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland.
Lancet Infect Dis. 2008 Jan;8(1):44-52. doi: 10.1016/S1473-3099(07)70311-0.
In several countries, pregnant women are recommended seasonal influenza vaccination and identified as a priority group for vaccination in the event of a pandemic. We review the evidence for the risks of influenza and the risks and benefits of seasonal influenza vaccination in pregnancy. Data on influenza vaccine safety in pregnancy are inadequate, but the few published studies report no serious side-effects in women or their infants, including no indication of harm from vaccination in the first trimester. National policies differ widely, mainly because of the limited data available, particularly on vaccination in the first trimester. The evidence of excess morbidity during seasonal influenza supports vaccinating healthy pregnant women in the second or third trimester and those with comorbidities in any trimester. The evidence of excess mortality in two previous influenza pandemics supports vaccinating in any trimester during a pandemic.
在一些国家，建议孕妇接种季节性流感疫苗，并在大流行期间将其确定为优先接种人群。我们回顾了流感风险以及孕期接种季节性流感疫苗的风险和益处的相关证据。关于孕期流感疫苗安全性的数据并不充分，但少数已发表的研究报告称，女性及其婴儿未出现严重副作用，包括没有迹象表明在孕早期接种疫苗会造成伤害。各国政策差异很大，主要是因为可用数据有限，尤其是关于孕早期接种疫苗的数据。季节性流感期间发病率过高的证据支持在孕中期或晚期为健康孕妇接种疫苗，以及为任何孕周患有合并症的孕妇接种疫苗。此前两次流感大流行期间死亡率过高的证据支持在大流行期间的任何孕周进行接种。
