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2
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本文引用的文献

1
Distribution of serogroups of Neisseria meningitidis and antigenic characterization of serogroup Y meningococci in Canada, January 1, 1999 to June 30, 2001.1999年1月1日至2001年6月30日加拿大脑膜炎奈瑟菌血清群分布及Y群脑膜炎球菌的抗原特性
Can J Infect Dis. 2002 Nov;13(6):391-6. doi: 10.1155/2002/891673.
2
Genetic analysis of Canadian isolates of C:2a:P1.2,5 and B:2a:P1.2,5 Neisseria meningitidis strains belonging to the hypervirulent clone of ET-15.对属于ET-15高毒力克隆的加拿大C:2a:P1.2,5和B:2a:P1.2,5血清群脑膜炎奈瑟菌菌株分离株的基因分析。
Can J Microbiol. 2004 Jun;50(6):433-43. doi: 10.1139/w04-024.
3
DNA Sequence analysis of the PorB protein of nonserotypeable serogroup C ET-15 meningococci suggests a potential mutational hot spot on their serotype antigens.不可分型C群ET-15脑膜炎球菌PorB蛋白的DNA序列分析表明，其血清型抗原上存在一个潜在的突变热点。
J Clin Microbiol. 2004 Jun;42(6):2718-23. doi: 10.1128/JCM.42.6.2718-2723.2004.
4
First report of capsule replacement among electrophoretic type 37 Neisseria meningitidis strains in Italy.意大利37型脑膜炎奈瑟菌菌株中荚膜置换的首次报告。
J Clin Microbiol. 2003 Dec;41(12):5783-6. doi: 10.1128/JCM.41.12.5783-5786.2003.
5
Capsule switching among C:2b:P1.2,5 meningococcal epidemic strains after mass immunization campaign, Spain.西班牙大规模免疫接种运动后C群：2b型：P1.2,5脑膜炎球菌流行菌株间的荚膜转换
Emerg Infect Dis. 2002 Dec;8(12):1512-4. doi: 10.3201/eid0812.020081.
6
Positive effect of meningococcal C vaccination on serogroup replacement in Neisseria meningitidis.脑膜炎球菌C疫苗接种对脑膜炎奈瑟菌血清群替代的积极影响。
Lancet. 2002 Sep 21;360(9337):953. doi: 10.1016/S0140-6736(02)11061-0.
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Meningococcal disease.脑膜炎球菌病
N Engl J Med. 2001 May 3;344(18):1378-88. doi: 10.1056/NEJM200105033441807.
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The changing epidemiology of meningococcal disease in the United States, 1992-1996.1992 - 1996年美国脑膜炎球菌病流行病学的变化
J Infect Dis. 1999 Dec;180(6):1894-901. doi: 10.1086/315158.
9
Proposed standardization of Neisseria meningitidis PorA variable-region typing nomenclature.脑膜炎奈瑟菌PorA可变区分型命名法的拟议标准化。
Clin Diagn Lab Immunol. 1998 Nov;5(6):845-55. doi: 10.1128/CDLI.5.6.845-855.1998.
10
Correlation between serological and sequencing analyses of the PorB outer membrane protein in the Neisseria meningitidis serotyping system.脑膜炎奈瑟菌血清分型系统中PorB外膜蛋白的血清学分析与测序分析之间的相关性
Clin Diagn Lab Immunol. 1998 May;5(3):348-54. doi: 10.1128/CDLI.5.3.348-354.1998.

从 Y 群到 B 群的潜在荚膜转换：导致加拿大侵袭性脑膜炎球菌病的三种奈瑟脑膜炎奈瑟菌分离株的特征。

Potential capsule switching from serogroup Y to B: The characterization of three such Neisseria meningitidis isolates causing invasive meningococcal disease in Canada.

机构信息

Laboratory for Pathogenic Neisseria and Vaccine Preventable Bacterial Diseases.

出版信息

Can J Infect Dis Med Microbiol. 2005 May;16(3):171-4. doi: 10.1155/2005/216369.

DOI:10.1155/2005/216369
PMID:18159539
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2095022/
Abstract

Three group B Neisseria meningitidis isolates, recovered from meningococcal disease cases in Canada and typed as B:2c:P1.5, were characterized. Multilocus sequence typing showed that all three isolates were related because of an identical sequence type (ST) 573. Isolates typed as 2c:P1.5 are common in serogroup Y meningococci but rare in isolates from serogroups B or C. Although no serogroup Y isolates have been typed as ST-573, eight isolates showed five to six housekeeping gene alleles that were identical to that of ST-573. This suggested that the B:2c:P1.5 isolates may have originated from serogroup Y organisms, possibly by capsule switching.

摘要

从加拿大脑膜炎球菌病病例中分离出的 3 株 B 群脑膜炎奈瑟菌分离株，经鉴定为 B:2c:P1.5。多位点序列分型显示，由于相同的序列型（ST）573，这 3 株分离株具有相关性。B:2c:P1.5 型分离株在 Y 群脑膜炎奈瑟菌中很常见，但在 B 群或 C 群分离株中很少见。尽管没有 Y 群分离株被鉴定为 ST-573，但 8 株分离株显示出 5 到 6 个看家基因等位基因与 ST-573 完全相同。这表明 B:2c:P1.5 分离株可能起源于 Y 群生物体，可能通过荚膜转换。