Tsang Raymond Sw, Squires Susan G, Zollinger Wendell D, Ashton Fraser E
CNS Infection Division, National Microbiology Laboratory, Winnipeg, Manitoba.
Can J Infect Dis. 2002 Nov;13(6):391-6. doi: 10.1155/2002/891673.
The relative frequency of serogroups of Neisseria meningitidis associated with meningococcal disease in Canada during the period January 1, 1999 to June 30, 2001 was examined. Of the 552 strains of N meningitidis collected from clinical specimens of normally sterile sites, 191 (34.6%), 276 (50.0%), 61 (11.1%) and 23 (4.2%) were identified by serological and molecular methods as serogroups B, C, Y and W135, respectively. About half (50.8%) of the serogroup Y isolates were isolated in the province of Ontario. The two most common serotypes found were 2c and 14. Most of the serogroup Y strains isolated from patients in Ontario were serotype 2c, while serotype 14 was the most common serotype associated with disease in the province of Quebec. The two most common serosubtypes found among the serogroup Y meningococci were P1.5 and P1.2,5. Laboratory findings, based on antigenic analysis, did not suggest that these serogroup Y strains arise by capsule switching from serogroups B and C strains. This study documented a higher incidence of finding serogroup Y meningococci in clinical specimens from patients in Ontario compared to the rest of Canada, and parallels the increase in serogroup Y meningococcal disease reported in some parts of the United States.
对1999年1月1日至2001年6月30日期间加拿大与脑膜炎球菌病相关的脑膜炎奈瑟菌血清群的相对频率进行了研究。从通常无菌部位的临床标本中收集的552株脑膜炎奈瑟菌中，通过血清学和分子方法分别鉴定出191株（34.6%）、276株（50.0%）、61株（11.1%）和23株（4.2%）为血清群B、C、Y和W135。约一半（50.8%）的血清群Y分离株是在安大略省分离出来的。发现的两种最常见血清型为2c和14。从安大略省患者中分离出的大多数血清群Y菌株为血清型2c，而血清型14是魁北克省与疾病相关的最常见血清型。在血清群Y脑膜炎球菌中发现的两种最常见血清亚型为P1.5和P1.2,5。基于抗原分析的实验室结果并不表明这些血清群Y菌株是通过从血清群B和C菌株进行荚膜转换产生的。这项研究记录了与加拿大其他地区相比，在安大略省患者的临床标本中发现血清群Y脑膜炎球菌的发生率更高，这与美国一些地区报告的血清群Y脑膜炎球菌病的增加情况相似。
