沙眼衣原体噬菌体：在急性冠状动脉事件中不起作用？
Chlamydial bacteriophage: No role in acute coronary events?
机构信息
University of British Columbia Centre for Disease Control.
出版信息
Can J Infect Dis Med Microbiol. 2005 Sep;16(5):298-300. doi: 10.1155/2005/173147.
BACKGROUND
A relationship between Chlamydia pneumoniae infection and acute coronary syndromes has not been consistently found in published studies. It has been hypothesized that a bacteriophage-infected subset of C pneumoniae may be uniquely equipped to promote atherosclerosis and acute coronary syndromes through the expression of phage genes.
METHODS
The authors performed a pilot case-control study of acute coronary events. Case and control subjects were characterized demographically and according to recognized coronary risk factors. These subjects also provided serum for the detection of antibody to the elementary bodies of C pneumoniae and antibody to the Vp1 protein coded by the phage. Bivariate and multivariate comparisons were performed using statistics appropriate for paired analyses.
RESULTS
Antibodies to C pneumoniae, Vp1 protein or both were not associated with acute coronary events by bivariate or multivariate analysis. As expected, case subjects were significantly more likely to have hypertension, hypercholesterolemia or diabetes mellitus.
CONCLUSION
The present study adds to a growing body of literature that does not support the hypothesized relationship between C pneumoniae (or a phage-infected subset of C pneumoniae) and acute coronary syndromes.
背景
在已发表的研究中，肺炎衣原体感染与急性冠状动脉综合征之间的关系尚未得到一致证实。据推测，感染噬菌体的肺炎衣原体亚群可能通过噬菌体基因的表达而具有独特的促进动脉粥样硬化和急性冠状动脉综合征的能力。
方法
作者对急性冠状动脉事件进行了一项试点病例对照研究。病例和对照受试者的特征是根据人口统计学和公认的冠状动脉危险因素进行描述。这些受试者还提供了血清，用于检测肺炎衣原体的原体抗体和噬菌体编码的 Vp1 蛋白抗体。使用适合配对分析的统计学方法进行了双变量和多变量比较。
结果
通过双变量或多变量分析，肺炎衣原体、Vp1 蛋白或两者的抗体均与急性冠状动脉事件无关。正如预期的那样，病例组受试者更有可能患有高血压、高胆固醇血症或糖尿病。
结论
本研究增加了越来越多的文献，这些文献不支持肺炎衣原体（或感染噬菌体的肺炎衣原体亚群）与急性冠状动脉综合征之间的假设关系。
Zotero 插件