Knight R A, Worman C P, Cawley J C
Clin Exp Immunol. 1983 Sep;53(3):600-4.
The autologous and allogeneic mixed lymphocyte reactions were measured using peripheral blood cells from 13 patients with hairy cell leukaemia (HCL), six of whom had been splenectomized when first studied. T cells from five patients responded to autologous stimulation, and one of these had received splenectomy. Significant alloreactivity was observed in nine patients, of whom three were splenectomized. An absent autologous reaction was associated with ratios of OKT4:OKT8 positive cells less than 1.5, and such ratios were more often observed after splenectomy. Non-T cells from 10 of 11 patients stimulated allogeneic normal T cells. The amounts of HLA-DR antigens on hairy cells were similar to those on normal peripheral blood non-T cells. These data suggest that the defects of response in HCL reflect abnormalities at the responder T cell level. Such defects may contribute to the defective host defence frequently observed in HCL.
使用13例毛细胞白血病（HCL）患者的外周血细胞来检测自体和异体混合淋巴细胞反应，其中6例在首次研究时已行脾切除术。5例患者的T细胞对自体刺激有反应，其中1例已接受脾切除术。在9例患者中观察到显著的异体反应性，其中3例已行脾切除术。自体反应缺失与OKT4:OKT8阳性细胞比例小于1.5相关，且脾切除术后更常观察到这种比例。11例患者中有10例的非T细胞刺激异体正常T细胞。毛细胞上HLA-DR抗原的量与正常外周血非T细胞上的相似。这些数据表明，HCL中反应缺陷反映了反应性T细胞水平的异常。这种缺陷可能导致HCL中经常观察到的宿主防御缺陷。
