Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
J Org Chem. 2011 Apr 15;76(8):2880-3. doi: 10.1021/jo101949y. Epub 2011 Mar 18.
A facile one-pot synthesis of pyrimidin-4(3H)-ones was developed via reactions of a series of readily available 3-aminopropenamides with varied Vilsmeier reagents, and a mechanism involving sequential halogenation, formylation, and intramolecular nucleophilic cyclization is proposed.
通过一系列易得的 3-氨基丙烯酰胺与不同的 Vilsmeier 试剂的一锅反应，开发了一种简便的嘧啶-4(3H)-酮合成方法，并提出了一个涉及顺序卤化、甲酰化和分子内亲核环化的反应机制。
