Santhakumari Rajani, Reddy Indla Yogananda, Archana R
Department of Physiology, MediCiti Institute of Medical Sciences, Hyderabad, Telangana, India.
Department of Physiology, Saveetha Medical College, Chennai, Tamilnadu, India.
Int J Pharma Bio Sci. 2014 Oct;5(4):1118-1123.
Cerebral metabolism will be affected in T2DM either by chronic hyperglycemia or by chronic hypoxia. Proton magnetic resonance spectroscopy (H-MRS) of the brain provides detailed information about the structure, dynamics, reaction state and chemical environment of molecules. It also measures the levels of brain metabolites such as myo-inositol (mI), N acetyl aspartate (NAA), creatine (Cr), choline (Cho), glutamate (Glu), glutamine (Gln) and gamma amino butyric acid (GABA). Several studies suggest that people with type 2 diabetes mellitus (T2DM) are at an increased risk of cognitive impairment in comparison with the general population. The altered metabolites may cause cognitive dysfunction in T2DM. This review article concludes that in T2DM, metabolite levels were altered in different regions of brain.
在2型糖尿病（T2DM）中，脑代谢会受到慢性高血糖或慢性缺氧的影响。脑部质子磁共振波谱（H-MRS）提供了有关分子结构、动力学、反应状态和化学环境的详细信息。它还能测量脑代谢物的水平，如肌醇（mI）、N-乙酰天门冬氨酸（NAA）、肌酸（Cr）、胆碱（Cho）、谷氨酸（Glu）、谷氨酰胺（Gln）和γ-氨基丁酸（GABA）。多项研究表明，与普通人群相比，2型糖尿病患者发生认知障碍的风险增加。代谢物改变可能导致T2DM患者出现认知功能障碍。这篇综述文章得出结论，在T2DM中，脑不同区域的代谢物水平发生了改变。
