Leclerc Jacques E, Leclerc Jean Thomas, Bernier Karine
Department of Otolaryngology-Head and Neck Surgery, Laval University, Quebec City, Canada.
Otolaryngol Head Neck Surg. 2008 Jan;138(1):43-9. doi: 10.1016/j.otohns.2007.09.020.
The purpose of this study was to determine the status of nasal airway and olfaction of adult subjects born with choanal atresia (CA).
A case-control study was conducted to compare the quality of nasal airway and olfaction in a group of adults born with CA to a similar group of normal subjects. Objective evaluation of nasal airway and olfaction were done respectively by acoustic rhinometry and the University of Pennsylvania Smell Identification Test (UPSIT).
Thirty-six choanal atresia patients aged 16 to 36 were found in the medical records. Five bilateral and two unilateral cases were recruited for the study. An average score of 27/40 (moderate hyposmia) was obtained by the bilateral cases compared with 37/40 (normal) by the controls. These results were statistically significant (Wilcoxon signed rank test and sign test statistic, P = 0.03).
Using the UPSIT, the bilateral CA patients have shown, on average, a moderate loss of the sense of smell when compared with normal controls of a similar age group. Acoustic rhinometry is not a useful study for posterior nasal conditions.
本研究旨在确定先天性后鼻孔闭锁（CA）成年患者的鼻气道和嗅觉状况。
进行了一项病例对照研究，以比较一组先天性后鼻孔闭锁成年患者与一组类似的正常受试者的鼻气道质量和嗅觉。分别通过鼻声反射和宾夕法尼亚大学嗅觉识别测试（UPSIT）对鼻气道和嗅觉进行客观评估。
在病历中发现了36例年龄在16至36岁的后鼻孔闭锁患者。招募了5例双侧和2例单侧病例进行研究。双侧病例的平均得分为27/40（中度嗅觉减退），而对照组为37/40（正常）。这些结果具有统计学意义（Wilcoxon符号秩检验和符号检验统计量，P = 0.03）。
使用UPSIT，与相似年龄组的正常对照组相比，双侧先天性后鼻孔闭锁患者平均表现出中度嗅觉丧失。鼻声反射对后鼻孔情况的研究无用。
