Rizvi Waseem, Fayazuddin Mohammad, Singh Ompal, Syed Shariq Naeem, Moin Shagufta, Akhtar Kafil, Kumar Anil
Department of Pharmacology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh 202002, India.
Department of Pharmacology, Raichur Institute of Medical Sciences, Raichur, 584101, India.
Avicenna J Phytomed. 2017 Jan-Feb;7(1):37-45.
In this study, we evaluated anti-inflammatory activity of leaves of () and underlying mechanisms by using models of inflammation.
Albino Wistar rats of either sex weighing 150 - 200 g were used. Soxhlet ethanol and aqueous extracts of leaves of (EFP and AFP) were prepared. The anti-inflammatory activity was studied using carrageenan-induced paw edema method and cotton pellet granuloma method. Levels of cytokines such as TNF-α, IL-6 and IL-1 and activity of antioxidant enzymes including catalase (CAT) and glutathione peroxidase (GPx) were estimated.
Leaves of demonstrated significant (p<0.001) decrease in paw edema in carrageenan-induced paw edema method. It diminished the serum tumour necrosis factor-α (TNF-α), IL-6 and IL-1 levels and also significantly attenuated the malondialdehyde (MDA) levels. The activity of CAT and GPx was increased in paw tissue. It also demonstrated significant decrease in granuloma formation in cotton pellet-induced granuloma method.
Leaves of possess anti-inflammatory activity as they inhibit various cytokines and have antioxidant effects and free radical scavenging activity.
在本研究中，我们通过使用炎症模型评估了（）叶的抗炎活性及其潜在机制。
使用体重为150 - 200克的白化Wistar大鼠，雌雄不限。制备了（）叶的索氏乙醇提取物和水提取物（EFP和AFP）。采用角叉菜胶诱导的足爪肿胀法和棉球肉芽肿法研究抗炎活性。估计了细胞因子如TNF-α、IL-6和IL-1的水平以及抗氧化酶包括过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GPx）的活性。
在角叉菜胶诱导的足爪肿胀法中，（）叶显示出足爪肿胀显著（p<0.001）减轻。它降低了血清肿瘤坏死因子-α（TNF-α）、IL-6和IL-1水平，并且还显著降低了丙二醛（MDA）水平。足爪组织中CAT和GPx的活性增加。在棉球诱导的肉芽肿法中，它还显示出肉芽肿形成显著减少。
（）叶具有抗炎活性，因为它们抑制多种细胞因子并具有抗氧化作用和自由基清除活性。
