Department of Marine Science, Qinzhou University, 89 Xihuan South Road, Qinzhou 535000, China.
J Ethnopharmacol. 2011 Oct 11;137(3):1177-82. doi: 10.1016/j.jep.2011.07.039. Epub 2011 Jul 22.
Sipunculus nudus has long been employed as traditional Chinese medicine in folk remedies for the treatment of carbuncles, tuberculosis and nocturia, regulating the functions of stomach and spleen, as well as for the restoration to health in debilities caused by various pathogens and aging. Decoction of Sipunculus nudus has traditionally been used to remedy sternalgia in folk medicine.
This study aimed to assess the anti-inflammatory and anti-nociceptive activity of the water extract from Sipunculus nudus.
The water extract from the body wall of Sipunculus nudus was obtained with the yield of 14.1%. The anti-inflammatory effect in six animal models and anti-nociceptive effect in two animal models of the water extract were evaluated by oral for the study.
Pretreatment with the extract (at the dose of 50, 100 and 200 mg/kg) produced significant dose-dependent anti-inflammatory and anti-nociceptive effects. At 200 mg/kg dose, the inhibition ratio of the extract on carrageenan-induced rat hind paw oedema, dextran-induced rat paw oedema, cotton pellet granuloma in rats, carrageenan-induced peritonitis and acetic acid-induced vascular permeability were 59.2%, 51.0%, 53.1%, 42.5%, 50.8%, better than that of indomethacin (5 mg/kg) 49.5%, 50%, 44.4%, 37.6%, 46.8%, respectively. The inhibition ratio of the extract (200 mg/kg dose) on xylene-induced mouse ear oedema was 61.5%, lower than 63.7% for indomethacin (5 mg/kg). At 200mg/kg, the extract decreased number of writhing 52.3% in acetic acid-induced writhing model and increased the response latency 25.24% in hot plate test.
The water extract from the body wall of Sipunculus nudus possesses excellent anti-inflammatory activity as well as peripheral and central analgesic properties.
海泥肠（Sipunculus nudus）长期以来一直被用作民间疗法中的传统中药，用于治疗痈疽、肺结核和夜尿症，调节胃脾功能，以及恢复因各种病原体和衰老导致的虚弱。海泥肠的汤剂传统上被用于民间医学治疗胸痛。
本研究旨在评估海泥肠水提取物的抗炎和镇痛活性。
采用水提法从海泥肠体壁中提取水提取物，产率为 14.1%。通过口服研究评估水提取物在六种动物模型中的抗炎作用和在两种动物模型中的镇痛作用。
提取物（剂量为 50、100 和 200mg/kg）预处理产生了显著的剂量依赖性抗炎和镇痛作用。在 200mg/kg 剂量下，提取物对角叉菜胶诱导的大鼠后足肿胀、葡聚糖诱导的大鼠足肿胀、大鼠棉塞肉芽肿、角叉菜胶诱导的腹膜炎和醋酸诱导的血管通透性的抑制率分别为 59.2%、51.0%、53.1%、42.5%、50.8%，优于吲哚美辛（5mg/kg）的 49.5%、50%、44.4%、37.6%、46.8%。提取物（200mg/kg 剂量）对二甲苯诱导的小鼠耳肿胀的抑制率为 61.5%，低于吲哚美辛（5mg/kg）的 63.7%。在 200mg/kg 剂量下，提取物可减少 52.3%的醋酸诱导扭体模型中的扭体次数，并增加 25.24%的热板试验中的反应潜伏期。
海泥肠体壁的水提取物具有出色的抗炎活性以及外周和中枢镇痛特性。
